1H, 13C and 15N resonance assignments for the human E2 conjugating enzyme, UbcH7
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UbcH7 is a human E2 conjugating enzyme in the ubiquitin-dependent protein degradation pathway. The resonance assignments of UbcH7 will assist in elucidating the structural basis of interactions that occur within ubiquitination.
KeywordsUbcH7 E2 conjugating enzyme Ubiquitin conjugation pathway Parkin
Really interesting new gene
Human homologue of Drosophila ariadne
Nuclear magnetic resonance
Heteronuclear single quantum correlation
The authors wish to thank Dr. Phillip Robinson and Dr. Helen Ardley for the UbcH7 plasmid. We would also like to thank Kathryn Barber for her technical support and Dr. Matthew Revington for his assistance in NMR data processing. This work was supported by grants from the Canadian Institutes of Health Research (CIHR), the Canada Research Chairs Program (G.S.S.), the CIHR Canada Graduate Scholarship (S.A.S.) and the Ontario Graduate Scholarship (S.A.S.).
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