NMR assignment of the C-terminal actin-binding domain of talin
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Talin is a large dimeric 270 kDa adapter protein which binds the cytoplasmic face of a subset of integrin β-subunits and couples them to the actin cytoskeleton. Here we report the near complete 15N, 13C and 1H chemical shift assignments for the C-terminal actin-binding domain.
KeywordsTalin Integrin Actin Cell–matrix adhesion Actin binding domain
The work was supported by a programme grant from the Wellcome Trust and a grant from the NIH Cell Migration Consortium.
- Hemmings L, Rees DJ, Ohanian V, Bolton SJ, Gilmore AP, Patel B, Priddle H, Trevithick JE, Hynes RO, Critchley DR (1996) Talin contains three actin-binding sites each of which is adjacent to a vinculin-binding site. J Cell Sci 109:2715–2726Google Scholar