NMR assignment of human chemerin, a novel chemoattractant
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Chemerin is a potent chemoattractant for cells expressing the GPCR CMKLR1, and is thought to play important roles in cell migration and recruitment to sites of tissue damage and inflammation. Here we report the NMR assignments of the 15.6 kDa active form of uniformly 15N, 13C labeled chemerin.
KeywordsChemerin Chemotaxis Inflammation CMKLR1
We thank David King (UC-Berkeley, CA) for mass spectrometry analysis, Peter Domaille (Diversa, San Diego, CA) for NMR data collection and Damon Hamel (UC-San Diego, CA) for help with data processing. This work was funded by Cancer Research Institute and Universitywide AIDS Research Program (TF06-SD-501) fellowships to S.J.A, and a National Institutes of Health grant RO1-AI37113 to T.M.H. B.A.Z. and E.C.B are funded by National Institutes of Health grants AI-59635, AI-47822, HL-67674 and GM-37734.
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