Backbone NMR assignment of the internal interaction site of ALP
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Earlier reports have shown that ALP has an internal interaction site. We were able to stablize the structure of this unfolded part to a great extent by aspartic acid, which allowed the backbone assignment. No secondary structure of the polypeptide was observed.
KeywordsNMR ALP Aspartic acid iHNCA
This work was financially supported by the Academy of Finland, Biocenter Oulu and Finnish Heart Foundation.