The Indian Journal of Pediatrics

, Volume 86, Issue 12, pp 1131–1135 | Cite as

CRISPR-Cas9 Probing of Infectious Diseases and Genetic Disorders

  • Sivaprakash RamalingamEmail author
  • Saravanabhavan ThangavelEmail author
Review Article


The ability to precisely change the deoxyribonucleic acid (DNA) bases at specific sites offers tremendous advantages in the field of molecular biology and medical biotechnology. Identification of Clustered Regularly-Interspaced Short Palindromic Repeats (CRISPR), revelation of its role in prokaryotic adaptive immunity and subsequent conversion into genome and epigenome engineering system are the landmark research progresses of the decade. The possibilities of deciphering the molecular mechanisms of the disease, identifying the disease targets, generating the disease models, validating the drug targets, developing resistance to the infection and correcting the genotype have brought off much enthusiasm in the field of infectious diseases and genetic disorders. This review focuses on CRISPR/Cas9’s impact in the field of infection and genetic disorders.


Targeted genome engineering/editing Zinc finger nucleases Transcription activator-like effector nucleases Clustered Regularly-Interspaced Short Palindromic Repeats (CRISPR)/CRISPR-associated systems (Cas9) Infectious diseases and genetic disorders 


Authors’ Contribution

SR and ST wrote the manuscript. SR is the guarantor for this paper.

Compliance with Ethical Standards

Conflict of Interest


Source of Funding

SR acknowledges Department of Biotechnology for the financial support. ST is supported by SERB (ECR/2015/000570) and Department of biotechnology (BT/PR26901/MED/31/377/2017).


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Copyright information

© Dr. K C Chaudhuri Foundation 2019

Authors and Affiliations

  1. 1.CSIR Institute for Genomics and Integrative Biology (IGIB)New DelhiIndia
  2. 2.Center for Stem Cell Research (CSCR), A Unit of inStem BengaluruChristian Medical College CampusVelloreIndia

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