The Indian Journal of Pediatrics

, Volume 86, Issue 6, pp 487–488 | Cite as

Monitoring Bone Health in Children with Hemophilic Arthropathy: Where Do We Stand?

  • Alpesh Goyal
  • Rajesh KhadgawatEmail author
Editorial Commentary

Osteoporosis is a systemic skeletal disease characterized by low bone mass and/or altered bone micro-architecture which results in decreased bone strength and increased risk for fractures. Children with hemophilic arthropathy are at an increased risk for secondary osteoporosis, which is contributed by following factors: a) reduced weight bearing and decreased muscle mass resulting in impaired muscle-bone cross talk, b) prolonged immobilization and c) associated co-morbidities (such as infections).

Bone mineral density (BMD) measured using dual-energy X-ray absorptiometry (DXA) is a strong predictor of future fracture risk, and is currently considered the gold standard for diagnosing osteoporosis. While BMD provides a good estimate of bone quantity, it fails to measure bone micro-architecture (or bone quality), which is an independent marker of bone health. Trabecular bone score (TBS) has recently emerged as a tool for measuring bone micro-architecture and has been shown to have a good...


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Copyright information

© Dr. K C Chaudhuri Foundation 2019

Authors and Affiliations

  1. 1.Department of EndocrinologyAll India Institute of Medical Sciences (AIIMS)New DelhiIndia

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