The Indian Journal of Pediatrics

, Volume 86, Issue 5, pp 401–402 | Cite as

Hypopituitarism Related Cholestatic Jaundice: Important to Recognise, Rewarding to Treat but Difficult to Diagnose!

  • Rishi Bolia
  • Anshu SrivastavaEmail author
Editorial Commentary

Congenital Hypopituitarism (CH) is defined as a deficiency of ≥2 pituitary hormones and can vary in severity and age at presentation. It has an incidence of 1–11/100,000 in the general pediatric population and may present in 1/3rd of cases as neonatal cholestasis (NC) [1, 2]. CH accounted for 1% of infants with NC in a pediatric hepatology centre in UK [1].

In this issue Altay et al. discuss the clinical features, laboratory parameters and outcomes of 6 children with CH who presented with NC at a median age of 2.5 mo. While 3 patients were diagnosed in their initial presentation, the remaining were diagnosed later in life [3].

Establishing a diagnosis of CH is challenging. Some of the clinical features like poor feeding, hypoglycemia, jaundice, apnea, jitteriness and poor weight gain are non-specific and one needs a high index of clinical suspicion to diagnose this condition. However, presence of visual problems, nystagmus, midline facial dysmorphism, and undescended testes/ micropenis...


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    Grammatikopoulos T, Deheragoda M, Strautnieks S, et al. Reduced hepatocellular expression of canalicular transport proteins in infants with neonatal cholestasis and congenital hypopituitarism. J Pediatr. 2018;200:181–7.CrossRefGoogle Scholar
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Copyright information

© Dr. K C Chaudhuri Foundation 2019

Authors and Affiliations

  1. 1.Division of Pediatric Gastroenterology Department of GastroenterologyPGIMERChandigarhIndia
  2. 2.Department of Pediatric GastroenterologySGPGIMSLucknowIndia

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