Cyclosporine in Resistant Systemic Arthritis - A Cheaper Alternative to Biologics

  • Priyankar PalEmail author
  • Prabhas Prasun Giri
  • Rajiv Sinha
Original Article



To assess the efficacy of cyclosporine (CsA) in patients of oral steroid unresponsive or steroid dependent systemic juvenile idiopathic arthritis (sJIA); to evaluate the optimum dosage and blood level of CsA to achieve and maintain remission and to observe for side-effects on prolonged usage.


This prospective observational study was conducted on children with steroid dependent /refractory sJIA admitted at the Institute of Child Health, Kolkata from July 2009 through November 2014. A total of 82 sJIA was diagnosed; 15 were steroid dependent /refractory and were included as candidates for cyclosporine therapy.


CsA was used in 15 patients; 13 showed a favourable response with significant steroid sparing effect and minimal toxicity.


CsA was found to be effective in almost 75% of frequently relapsing steroid dependent sJIA to achieve and maintain remission. The average cost of therapy for a 20 kg patient on CsA was found to be 10,000 INR (132 EURO)/ patient over a 6 mo period; which would amount to 100,000 INR (1318 EURO)/patient with Tocilizumab for the same duration.


Systemic arthritis Cyclosporine Systemic juvenile idiopathic arthritis treatment 


Authors’ Contribution

PP conceptualised the project. Both PP and PPG were involved in patient management and data collection. All three authors drafted the manuscript. Prof. Apurba Ghosh, Director, Institute of Child Health, Kolkata will act as guarantor for this paper.

Compliance with Ethical Standards

Conflict of Interest



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Copyright information

© Dr. K C Chaudhuri Foundation 2019

Authors and Affiliations

  • Priyankar Pal
    • 1
    Email author
  • Prabhas Prasun Giri
    • 2
  • Rajiv Sinha
    • 3
  1. 1.Department of Pediatrics, Pediatric Rheumatology UnitInstitute of Child HealthKolkataIndia
  2. 2.Department of PediatricsInstitute of Child HealthKolkataIndia
  3. 3.Pediatric Nephrology Unit, Department of PediatricsInstitute of Child HealthKolkataIndia

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