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The Indian Journal of Pediatrics

, Volume 86, Issue 4, pp 379–381 | Cite as

Treatment of Elizabethkingia meningoseptica Neonatal Meningitis with Combination Systemic and Intraventricular Therapy

  • Preetha Joshi
  • Bhavya Shah
  • Vinay Joshi
  • Abhaya Kumar
  • Tanu SinghalEmail author
Clinical Brief
  • 113 Downloads

Abstract

Elizabethkingia meningoseptica, a gram negative bacillus ubiquitous in the hospital environment, is known to infrequently cause serious neonatal infections, particularly meningitis which is associated with high mortality and neuromorbidity in survivors. The authors describe a healthy term newborn with no apparent risk factors who developed Elizabethkingia meningoseptica sepsis and meningitis on day 6 of life. Diagnosis could be established only after a week of the illness by which time the baby developed refractory status epilepticus, ventriculitis and hydrocephalus. The isolate was susceptible to only ciprofloxacin, tigecycline and rifampicin and resistant to vancomycin. Apart from systemic combination therapy for 12 wk, intraventricular vancomycin was given through an external ventricular drain for 4 wk and later a ventriculo-peritoneal (VP) shunt was inserted. With this regime, authors demonstrated microbiologic and clinical cure. The baby is neurologically normal over a 6 mo follow-up.

Keywords

Elizabethkingia Meningitis Intraventricular Vancomycin Neonate 

Notes

Acknowledgements

The authors acknowledge help of Sweta Shah, Department of Microbiology for helping in identification and susceptibility testing and Pradnya Gadgil, Pediatric Neurologist.

Authors’ Contributions

PJ: Intensive care management and drafting of manuscript; BS: Clinical management, literature search and drafting of manuscript; VJ: Intensive care management and drafting of manuscript; AK: Neurosurgical management and drafting of manuscript; TS: Infectious disease opinion and reviewing the manuscript. TS will act as guarantor for this paper.

Compliance with Ethical Standards

Conflict of Interest

None.

Source of Funding

None.

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Copyright information

© Dr. K C Chaudhuri Foundation 2019

Authors and Affiliations

  • Preetha Joshi
    • 1
  • Bhavya Shah
    • 1
  • Vinay Joshi
    • 1
  • Abhaya Kumar
    • 2
  • Tanu Singhal
    • 3
    Email author
  1. 1.Department of Neonatal Critical CareKokilaben Dhirubhai Ambani Hospital and Medical Research InstituteMumbaiIndia
  2. 2.Department of NeurosurgeryKokilaben Dhirubhai Ambani Hospital and Medical Research InstituteMumbaiIndia
  3. 3.Department of PediatricsKokilaben Dhirubhai Ambani Hospital and Medical Research InstituteMumbaiIndia

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