The Indian Journal of Pediatrics

, Volume 85, Issue 11, pp 1028–1030 | Cite as

Van Wyk Grumbach Syndrome: A Rare Consequence of Hypothyroidism

  • Pavan ReddyEmail author
  • Kritika Tiwari
  • Abhishek Kulkarni
  • Ketan Parikh
  • Raju Khubchandani
Clinical Brief


Long standing hypothyroidism presenting as an ovarian mass has been well described in literature as the Van Wyk Grumbach syndrome (hypothyroidism, isosexual precocious puberty and ovarian mass). Here, authors report this entity in a 11 y 7 mo old girl child who was referred to a surgeon in view of intestinal obstruction along with a multiloculated ovarian cyst. On evaluation, she was found to have raised serum creatinine, short stature, delayed bone age and pituitary enlargement. She was diagnosed with autoimmune thyroiditis and was started on replacement therapy with thyroxine, after which the ovarian cysts regressed. This entity should be kept in mind in cases of ovarian cysts, especially those with isosexual precocity, to prevent unnecessary evaluation and surgical misadventures.


Hypothyroidism Precocious puberty Ovarian mass Van Wyk Grumbach syndrome 


Author Contributions

PR: Work up of the case, followed up the case, reviewed the literature and drafted the manuscript; KT: Reviewed the literature and drafted the manuscript; AK: Work up and management of the case; KP: Diagnosis and management of the case; RK: Work up and management of the case, evaluation of manuscript and gave final approval; RK will act as guarantor for the paper.

Compliance with Ethical Standards

Conflict of Interest



  1. 1.
    Van Wyk JJ, Grumbach MM. Syndrome of precocious menstration and galactorrhea in juvenile hypothyroidism: an example of hormonal overlap in pituitary feedback. J Pediatr. 1960;57:416–35.CrossRefGoogle Scholar
  2. 2.
    Rastogi A, Bhadada SK, Bhansali A. An unusual presentation of a usual disorder: Van Wyk-Grumbach syndrome. Indian J Endocrinol Metab. 2011;15:141–3.CrossRefGoogle Scholar
  3. 3.
    Kendle FW. Case of precocious puberty in a female cretin. Br Med J. 1905;1:246.CrossRefGoogle Scholar
  4. 4.
    Philip R, Saran S, Gutch M, Gupta KK. An unusual case of precocious puberty and macroorchidism. Thyroid Res Pract. 2013;10:29–31.CrossRefGoogle Scholar
  5. 5.
    Anasti JN, Flack MR, Froehlich J, Nelson LM, Nisula BC. A potential novel mechanism for precocious puberty in juvenile hypothyroidism. J Clin Endocrinol Metab. 1995;80:276–9.PubMedGoogle Scholar
  6. 6.
    Desai MP, Mehta RU, Choksi CS, Colaco MP. Pituitary enlargement on magnetic resonance imaging in congenital hypothyroidism. Arch Pediatr Adolesc Med. 1996;150:623–8.CrossRefGoogle Scholar
  7. 7.
    Motamed F, Eftekhari K, Kiani MA, Rabbani A. Ovarian cyst enlargement in a 14 year old female with persistent ascities, severe hypothyroidism and elevated serum CA-125 level. Iran Red Crescent Med J. 2012;14:379–81.PubMedPubMedCentralGoogle Scholar
  8. 8.
    Connor A, Taylor JE. Renal impairment resulting from hypothyroidism. NDT Plus. 2008;1:440–1.PubMedPubMedCentralGoogle Scholar
  9. 9.
    Sanjeevaiah AR, Sanjay S, Deepak T. Precocious puberty and large multicystic ovaries in young girls with primary hypothyroidism. Endocr Pract. 2007;13:652–5.CrossRefGoogle Scholar

Copyright information

© Dr. K C Chaudhuri Foundation 2018

Authors and Affiliations

  1. 1.Department of PediatricsJaslok Hospital and Research CentreMumbaiIndia

Personalised recommendations