Eosinophilic Esophagitis – An Overview
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Eosinophilic Esophagitis (EoE) is a chronic, immune mediated, clinico-pathological disorder characterized by symptoms of esophageal dysfunction and eosinophil-predominant inflammation of esophageal mucosa .
EoE was once considered to be a rare entity in pediatric population but incidence of this condition is rapidly rising across the globe specially in western countries. This has led to increase in both awareness and research surrounding this condition. Prevalence of EoE is estimated to be 0.5–1 cases/1000 persons in western countries, making this condition as common as inflammatory bowel disease . The data on prevalence of EoE in India is scarce. A small study from a tertiary care center in northwestern India reported that 3.9% of pediatric patients undergoing elective esophagogastroduodenoscopy (EGD) were found to have EoE .
Symptoms of EoE can be vague in children and can vary based on patient’s age. Younger children commonly present with feeding difficulties, vomiting,...
Dr. Gupta is supported in part by Consortium of Eosinophilic Gastrointestinal Disease Researchers (U54 AI117804), a part of the Rare Diseases Clinical Research Network (RDCRN), an initiative of the Office of Rare Diseases Research (ORDR), NCATS, and is funded through collaboration between NIAID, NIDDK, and NCATS. CEGIR is also supported by patient advocacy groups including APFED, CURED and EFC.
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Conflict of Interest
Dr. Gupta serves as consultant for Allakos, Abbott, Receptos, QOL and receives research support from Shire.
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