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A Comparative Evaluation of Presepsin with Procalcitonin and CRP in Diagnosing Neonatal Sepsis

  • Neeraj Kumar
  • Rajeshwar Dayal
  • Pratibha Singh
  • Sunit Pathak
  • Vishal Pooniya
  • Ankur Goyal
  • Raj Kamal
  • K. K. Mohanty
Clinical Brief

Abstract

The objectives of this study were to study the clinical and biochemical profile of neonates with sepsis and to evaluate the diagnostic role of presepsin and its comparison with C-reactive protein (CRP) and Procalcitonin (PCT). This study was conducted from March 2015 through October 2016 in Neonatal intensive care unit (NICU) at S N Medical College, Agra. Neonates with ≥1 clinical features of sepsis and/or two risk factors were included. A total of 41 cases and 41 controls were taken. Blood sample was taken for all investigations. ROC curve analysis was performed. Out of 41 cases, 19 were blood culture positive, majority were males (68.3%), low birth weight (LBW: 70.7%) and preterms (53.6%). At chosen cut-off values, sensitivity of CRP, PCT and presepsin was 80.5%, 80.5%, 97.6% and specificity was 97.5%, 80.5%, 95.1% respectively. PCT and CRP were comparable as diagnostic markers of neonatal sepsis. Presepsin, in comparison with CRP and PCT has better sensitivity and negative predictive value (NPV).

Keywords

CRP Procalcitonin Presepsin Comparison Neonatal Sepsis 

Notes

Contributions

NK and RD: Planned the study; PS: Collected and analyzed the data; KKM and AG: Laboratory measurements were supervised; SP, VP and RK: Data was interpreted. All authors approved the final draft. RD will act as guarantor for this paper.

Compliance with Ethical Standards

Conflict of Interest

None.

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Copyright information

© Dr. K C Chaudhuri Foundation 2018

Authors and Affiliations

  1. 1.Department of PediatricsSarojini Naidu Medical CollegeAgraIndia
  2. 2.Department of PediatricsFH Medical CollegeTundlaIndia
  3. 3.Department of PediatricsKing George’s Medical UniversityLucknowIndia
  4. 4.Department of MicrobiologySarojini Naidu Medical CollegeAgraIndia
  5. 5.Department of Clinical MedicineNational JALMA Institute for Leprosy and other Mycobacterial Diseases (ICMR)AgraIndia

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