Bacterial Infections of the Central Nervous System

Review Article
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Abstract

Bacterial infections of the central nervous system (CNS) continue to be an important cause of morbidity and mortality in children. The spectrum of bacterial infection of CNS includes; focal or multifocal infections like brain abscesses or subdural empyema; or more generalized or diffuse infections like pyogenic meningitis or ventriculitis. Focal and generalized infections may co-exist in an individual patient. Prompt and adequate antibiotic therapy and occasionally neurosurgical interventions are the cornerstone of effective management. The recent emergence of several multidrug-resistant bacteria poses a threat to the effective management of bacterial CNS infections. Several adjunctive anti-inflammatory and neuroprotective therapies are being tried, however; none has made a remarkable impact on the outcome. Consequently, bacterial CNS infections in children still remain a challenge to manage. In this review, authors discuss the current updates on the diagnostic and therapeutic aspects of bacterial infections of the CNS in children (post-neonatal age group).

Keywords

Neuroinfections Pyomeningitis Intracranial suppuration Pyogenic brain abscess Bacterial meningitides 

Notes

Contributions

RS: Reviewed the literature, wrote the manuscript; NS: Reviewed the literature, and finalized the manuscript.

Compliance with Ethical Standards

Conflict of Interest

None.

Source of Funding

None.

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Copyright information

© Dr. K C Chaudhuri Foundation 2018

Authors and Affiliations

  1. 1.Pediatric Neurology and Neurodevelopment Unit, Department of Pediatrics, Advanced Pediatric CentrePost Graduate Institute of Medical Education and ResearchChandigarhIndia

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