The Indian Journal of Pediatrics

, Volume 84, Issue 6, pp 494–495 | Cite as

Novel Mutation in SH2 Domain of STAT3 (p.M660T) in Hyper-IgE Syndrome with Sterno-Clavicular and Paravertebral Abscesses

  • Biman Saikia
  • Shubham Goel
  • Deepti Suri
  • Ranjana W. Minz
  • Amit Rawat
  • Surjit Singh
Scientific Letter


Amino Acid Change Cloxacillin Absolute Eosinophil Count Cotrimoxazole Prophylaxis Paravertebral Abscess 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Compliance with Ethical Standards

Conflict of Interest


Source of Funding

Indian Council of Medical Research, New Delhi.


  1. 1.
    Grimbacher B, Holland SM, Puck JM. Hyper-IgE syndromes. Immunol Rev. 2005;203:244–50.CrossRefPubMedGoogle Scholar
  2. 2.
    Giacomelli M, Tamassia N, Moratto D, et al. SH2-domain mutations in STAT3 in hyper-IgE syndrome patients result in impairment of IL-10 function. Eur J Immunol. 2011;41:3075–84.CrossRefPubMedGoogle Scholar

Copyright information

© Dr. K C Chaudhuri Foundation 2017

Authors and Affiliations

  1. 1.Department of ImmunopathologyPostgraduate Institute of Medical Education and ResearchChandigarhIndia
  2. 2.Department of PediatricsPostgraduate Institute of Medical Education and ResearchChandigarhIndia

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