The Indian Journal of Pediatrics

, Volume 84, Issue 6, pp 417–419 | Cite as

Prevalence of Asymptomatic Microalbuminuria in HIV Positive Children in India

Original Article



To study the prevalence of covert or early renal involvement among human immunodeficiency virus (HIV) positive children.


A cross-sectional observational study was carried out on 250 HIV positive children (2–18 y) on follow-up in a tertiary care hospital from January 2014 through June 2015. Those who met the study criteria were evaluated for microalbuminuria and glomerular and tubular dysfunctions.


Fifty-one out of two hundred fifty (20%) children were found to have microalbuminuria though none had any other evidence of renal dysfunction. The incidence of microalbuminuria in children on Anti Retroviral Therapy (ART) and those not on ART was 20% and 21% respectively. Neither was there any difference in those with a CD4 count ≤500/cu mm compared with those with counts >500/cu mm. However, the overall CD4 counts were significantly lower in children with microalbuminuria.


Microalbuminuria was detected in 20% of asymptomatic HIV positive children suggesting early glomerular dysfunction and need for regular screening and follow-up.


HIV positive children HIVAN Microalbuminuria 



GS collected the data and wrote the initial draft; SSM planned the study, supervised the data collection and edited and corrected the paper. SSM will act as guarantor for the paper.

Compliance with Ethical Standards

Conflict of Interest


Source of Funding



  1. 1.
    Rademacher ER, Sinaiko AR. Albuminuria in children. Curr Opin Nephrol Hypertens. 2009;18:246–51.CrossRefPubMedGoogle Scholar
  2. 2.
    Anochie IC, Eke FU, Okpere AN. Human immunodeficiency virus-associated nephropathy (HIVAN) in Nigerian children. Pediatr Nephrol. 2008;23:117–22.CrossRefPubMedGoogle Scholar
  3. 3.
    Esezobor CI, Iroha E, Onifade E, Akinsulie AO, Temiye EO, Ezeaka C. Prevalence of proteinuria among HIV-infected children attending a tertiary hospital in Lagos, Nigeria. J Trop Pediatr. 2010;56:187–90.Google Scholar
  4. 4.
    Gupta V, Gupta S, Sinha S, et al. HIV associated renal disease: a pilot study from North India. Indian J Med Res. 2013;137:950–6.PubMedPubMedCentralGoogle Scholar
  5. 5.
    Szczech LA, Grunfeld C, Scherzer R, et al. Microalbuminuria in HIV infection. AIDS. 2007;21:1003–9.CrossRefPubMedPubMedCentralGoogle Scholar
  6. 6.
    Mosten IK, Hamel BC, Kinabo GD. Prevalence of persistent microalbuminuria and associated factors among HIV infected children attending a tertiary hospital in northern Tanzania: a cross sectional, analytical study. Pan Afr Med J. 2015;20:250–1.CrossRefGoogle Scholar
  7. 7.
    Chaparro AI, Mitchell CD, Abitbol CL, et al. Proteinuria in children infected with the human immunodeficiency virus. J Pediatr. 2008;152:844–9.CrossRefPubMedGoogle Scholar
  8. 8.
    Ekulu PM, Nseka NM, Aloni MN, et al. Prevalence of proteinuria and its association with HIV/AIDS in Congolese children living in Kinshasa. Democratic Republic of Congo Nephrol Ther. 2012;8:163–7.PubMedGoogle Scholar
  9. 9.
    Ramezani A, Mohraz M, Banifazl M, et al. Frequency and associated factors of proteinuria in Iranian HIV-positive patients. Int J Infect Dis. 2008;12:490–4.CrossRefPubMedGoogle Scholar
  10. 10.
    Kwak BO, Lee ST, Chung S, Kim KS. Microalbuminuria in normal Korean children. Yonsei Med J. 2011;52:476–81.CrossRefPubMedPubMedCentralGoogle Scholar
  11. 11.
    Labarga P, Barreiro P, Martin-Carbonero L, et al. Kidney tubular abnormalities in the absence of impaired glomerular function in HIV patients treated with tenofovir. AIDS. 2009;23:689–96.CrossRefPubMedGoogle Scholar
  12. 12.
    Wali RK, Drachenberg CI, Papadimitriou JC, Keay S, Ramos E. HIV-1-associated nephropathy and response to HAART. Lancet. 1998;352:783–4.CrossRefPubMedGoogle Scholar

Copyright information

© Dr. K C Chaudhuri Foundation 2017

Authors and Affiliations

  1. 1.Department of PediatricsArmed Forces Medical CollegePuneIndia

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