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The Indian Journal of Pediatrics

, Volume 83, Issue 4, pp 289–293 | Cite as

Effect of Zinc Supplementation on Early Outcome of Neonatal Sepsis - A Randomized Controlled Trial

  • Banupriya Newton
  • Ballambattu Vishnu Bhat
  • Benet Bosco Dhas
  • Nivedita Mondal
  • Sridhar Magadi Gopalakrishna
Original Article

Abstract

Objective

To find the effect of zinc supplementation on the outcome of neonatal sepsis at one month of age.

Methods

This randomized controlled trial was conducted in a tertiary care neonatal unit, enrolling neonates with clinical features of sepsis and positive blood culture or positive sepsis screening tests. The treatment group received 3 mg/kg/twice a day of zinc sulfate monohydrate orally for 10 d along with standard antibiotic therapy. The control group received standard antibiotic treatment without zinc. Samples were collected from both the groups before and after the treatment. Babies were monitored till discharge and followed up as out-patients till one month of age.

Results

Demographic characteristics were similar between the cases and controls. After 10 d of treatment, the mean serum zinc level between the two groups was 737.09 ± 219.97 vs. 801.26 ± 405.56, (p = 0.20). Outcome measures like days of hospital stay (15 vs. 15; p = 0.69) and mortality rate (4.5 % vs. 13.6 %; p = 0.27) were not found to be significantly different between the groups. At one month of age, more number of control neonates had abnormal neurological findings as compared to the zinc supplemented group [(P = 0.02); RR (95%CI) = 0.28 (0.11–0.73)].

Conclusions

Zinc supplementation in neonates with sepsis improves the neurological status at one month of age although the mortality reduction was not statistically significant.

Keywords

Neonatal sepsis Zinc supplementation Mortality Neurological status 

Notes

Acknowledgments

The assistance in statistical analysis by Dr. Palanivel and Dr. Divya, Department of P&SM, is acknowledged. The authors are thankful to Dr.Toteja from Indian Council of Medical Research (ICMR), New Delhi for estimating the serum zinc levels.

Contributions

BBD and BVB designed the study. BN has done laboratory works and drafted the manuscript. NM assessed the neurological outcome of the babies. BVB, SMG and NM reviewed the manuscript. BVB will act as guarantor for the paper.

Conflict of Interest

None.

Source of Funding

Extramural Research Grant, Indian Council of Medical Research (ICMR), New Delhi.

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Copyright information

© Dr. K C Chaudhuri Foundation 2015

Authors and Affiliations

  • Banupriya Newton
    • 1
  • Ballambattu Vishnu Bhat
    • 1
  • Benet Bosco Dhas
    • 1
  • Nivedita Mondal
    • 1
  • Sridhar Magadi Gopalakrishna
    • 2
  1. 1.Department of NeonatologyJawaharlal Institute of Postgraduate Medical Education and ResearchPondicherryIndia
  2. 2.Department of BiochemistryJawaharlal Institute of Postgraduate Medical Education and ResearchPondicherryIndia

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