Probiotics in Pediatrics
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Probiotics refer to the live microorganisms which, when ingested in an adequate amount, provide health benefit to the host. Most of the probiotics are bacteria, while Saccharomyces boulardii is a yeast . The postulated mechanisms by which probiotics exert their beneficial effects include improvement in host barrier function, competitive inhibition of pathogenic bacteria, strengthening of tight junctions between enterocytes, promoting maturation of the intestinal brush border membrane and stimulation of production of secretory IgA.
There has been substantial evidence in the recent past to suggest some beneficial effects of probiotics in the treatment of acute diarrhea in children. The recent Cochrane review on the use of probiotics for treating acute infectious diarrhea, which included 63 trials (56 in infants and children), reported shortened duration of diarrhea by 25 h (95 % CI 15.9 to 33.6 h), decrease in the risk of diarrhea lasting four or more days by 59 % and one fewer loose...
KeywordsDiarrhea Lactobacillus Atopic Dermatitis Lactobacillus Acidophilus Oral Rehydration Solution
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- 9.Osborn DA, Sinn JK. Probiotics in infants for prevention of allergic disease and food hypersensitivity. Cochrane Database Syst Rev. 2007;4:CD006475. doi: 10.1002/14651858.CD006475.pub2.
- 11.WHO/UNICEF: Joint statement: clinical management of acute diarrhea (WHO/FCH/CAH/04.07). Geneva & New York: World Health Organization, Department of Child and Adolescent Health and Development, and the United Nations Children’s Fund, Programme Division; 2004.Google Scholar