The Indian Journal of Pediatrics

, Volume 82, Issue 3, pp 221–224 | Cite as

Serum Bisphenol A Concentration and Premature Thelarche in Female Infants Aged 4-month to 2-year

  • Lian-hui Chen
  • Jian-rong Shi
  • Yan-lan FangEmail author
  • Li Liang
  • Wan-qin Chen
  • Xiao-zhen Chen
Original Article



To estimate the association between serum bisphenol A and premature thelarche in female infants aged 4-mo to 2-y.


A total of 251 female infants (aged 4 mo to 2 y) with premature thelarche and 33 healthy age-matched control subjects were analyzed. All participants underwent physical examination and serum bisphenol A was measured by ultra-performance liquid chromatography tandem mass spectrometry.


Serum bisphenol A concentration in the premature thelarche group (3.48 ng/ml, 95%CI: 0.09-140.26) was significantly higher than that in the control group (1.70 ng/ml, 95%CI: 0.06–51.78) (p = 0.039). There was no correlation between age and serum bisphenol A (BPA) level. Univariate logistic regression analysis showed that serum BPA concentration positively associated with premature thelarche, and the effect of BPA fell down as the age grew.


This hospital-based study implied that there is an association between serum BPA concentrations and premature thelarche. Additionally, serum BPA levels were markedly higher in infants aged 4-mo to 2-y-old, raising a concern for public health authorities.


Premature thelarche Bisphenol A Infants 



The authors would like to thank the children and their parents who participated in the study.


LHC, YLF, LL: Conceived and designed the research; JRS, WQC, XZC: Collected the data; LHC, YLF: Analyzed the data; YLF: Act as guarantor for this paper; LHC, JRS, YLF: Wrote the paper.

Conflict of Interest


Source of Funding

The Medical Science and Technology Program of Zhejiang province (2012RCA039) funded the study.


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Copyright information

© Dr. K C Chaudhuri Foundation 2014

Authors and Affiliations

  • Lian-hui Chen
    • 1
  • Jian-rong Shi
    • 2
  • Yan-lan Fang
    • 1
    Email author
  • Li Liang
    • 1
  • Wan-qin Chen
    • 3
  • Xiao-zhen Chen
    • 3
  1. 1.Department of Pediatrics, The First Affiliated Hospital of College of MedicineZhejiang UniversityHangzhouChina
  2. 2.Laboratory Center of Children’s HospitalZhejiang University School of MedicineHangzhouChina
  3. 3.Zhejiang Quality Inspection Institute of ScienceHangzhouChina

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