Systemic Effects of Perinatal Asphyxia
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Perinatal asphyxia is one of the three most important causes of neonatal mortality and morbidity . It is a major contributor to long term neurodevelopmental sequele in the developing world. During fetal hypoxia-ischemia, ‘diving reflex’ shunts blood from ‘non-vital areas’ such as skin and splanchnic circulation to the ‘vital organs’ like heart, adrenals, and brain to protect them from injury. Thus theoretically, any newborn with neurological injury due to asphyxia should also have derangements of the ‘non-vital organs’ like kidney and gut. However, even in cases of severe intrapartum asphyxia, the involvement of various organs is not consistent and ranges from 70 to 100 % [2, 3]. There could be multiple reasons behind this variation: (a) all organs may not be equally involved due to variable activation of ‘diving reflex’ , (b) use of different criteria to define multi-organ dysfunction (MOD) and asphyxia, and (c) variable timing of clinical and laboratory evaluation. The...
KeywordsCardiac Injury Perinatal Asphyxia Birth Asphyxia Anterior Wall Myocardial Infarction Acute Kidney Injury Criterion
AB: Did the literature search and formulated the draft; PK: Conceptualized the draft, critically evaluated, revised and finalized the manuscript. He will act as guarantor for this paper.
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