Group B Streptococcal Meningitis in Infants Beyond the Neonatal Period
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To describe the clinico-bacteriological profile, and early outcomes of infants diagnosed with Group B streptococcus (GBS) meningitis.
This was a retrospective review of infants (aged 1 mo to 2 y) diagnosed with GBS meningitis in a tertiary care hospital in New Delhi from October 2010 through January 2012. The clinico-bacteriological data and early outcomes of infants with suspected bacterial meningitis and a positive CSF latex agglutination test for GBS were studied. The CSF samples were subjected to PCR for broad spectrum 16s ribosomal DNA and the GBS species specific gene, the scpB.
Twenty seven patients (13 boys, and 14 girls) were diagnosed with GBS meningitis during the study period. Broad spectrum 16s ribosomal DNA PCR was performed on 18 of the 27 CSF samples. Sixteen were positive. All these 16 were also positive for the species specific scpB gene. The median duration of hospital stay was 7 d (range 1–72 d). Nine patients died. One patient each developed ventriculitis, optic atrophy and hydrocephalus. Overall, 12 patients had a complete recovery at discharge.
GBS must be considered in the etiology of bacterial meningitis in Indian infants.
KeywordsBacterial meningitis Scp gene Ventriculitis
The data in this study was a subset from a project on surveillance for Hemophilus influenzae B meningitis. The authors wish to thank Dr Amit Kumar, Research officer, laboratory technicians Priyanka Panchal, Md. Shakir Khan and Arvind Kumar; and lab attendant Rohit Kumar at Lady Hardinge Medical College.
SA was the site principal investigator in the surveillance project. SA, AC, SB and BKD were involved in the concept and design of the study, and were also investigators in the surveillance project. SD performed and supervised the microbiological studies. The data was collected by SS. GK and SPF trained the technicians and standardized the microbiological procedures. MC and NW supervised the clinical data collection and the microbiological procedures. The first draft of the manuscript was written by SD and SS, which was finally approved by all the authors.
Conflict of Interest
Role of Funding Source
The project was funded by the Johns Hopkins Institute, Baltimore.
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