The Indian Journal of Pediatrics

, Volume 81, Issue 1, pp 4–8 | Cite as

Group B Streptococcal Meningitis in Infants Beyond the Neonatal Period

  • Shalini Dwivedi
  • Bimal K. Das
  • Satinder Aneja
  • Suvasini Sharma
  • Mona K. Chaturvedi
  • Geoff Kahn
  • Sean P. Fitzwater
  • Aruna Chandran
  • Nitya Wadhwa
  • Shinjini Bhatnagar
Original Article



To describe the clinico-bacteriological profile, and early outcomes of infants diagnosed with Group B streptococcus (GBS) meningitis.


This was a retrospective review of infants (aged 1 mo to 2 y) diagnosed with GBS meningitis in a tertiary care hospital in New Delhi from October 2010 through January 2012. The clinico-bacteriological data and early outcomes of infants with suspected bacterial meningitis and a positive CSF latex agglutination test for GBS were studied. The CSF samples were subjected to PCR for broad spectrum 16s ribosomal DNA and the GBS species specific gene, the scpB.


Twenty seven patients (13 boys, and 14 girls) were diagnosed with GBS meningitis during the study period. Broad spectrum 16s ribosomal DNA PCR was performed on 18 of the 27 CSF samples. Sixteen were positive. All these 16 were also positive for the species specific scpB gene. The median duration of hospital stay was 7 d (range 1–72 d). Nine patients died. One patient each developed ventriculitis, optic atrophy and hydrocephalus. Overall, 12 patients had a complete recovery at discharge.


GBS must be considered in the etiology of bacterial meningitis in Indian infants.


Bacterial meningitis Scp gene Ventriculitis 



The data in this study was a subset from a project on surveillance for Hemophilus influenzae B meningitis. The authors wish to thank Dr Amit Kumar, Research officer, laboratory technicians Priyanka Panchal, Md. Shakir Khan and Arvind Kumar; and lab attendant Rohit Kumar at Lady Hardinge Medical College.


SA was the site principal investigator in the surveillance project. SA, AC, SB and BKD were involved in the concept and design of the study, and were also investigators in the surveillance project. SD performed and supervised the microbiological studies. The data was collected by SS. GK and SPF trained the technicians and standardized the microbiological procedures. MC and NW supervised the clinical data collection and the microbiological procedures. The first draft of the manuscript was written by SD and SS, which was finally approved by all the authors.

Conflict of Interest


Role of Funding Source

The project was funded by the Johns Hopkins Institute, Baltimore.


  1. 1.
    Schuchat A. Group B, streptococcus. Lancet. 1999;353:51–6.PubMedCrossRefGoogle Scholar
  2. 2.
    Shet A, Ferrieri P. Neonatal & maternal group B streptococcal infections: A comprehensive review. Indian J Med Res. 2004;120:141–50.PubMedGoogle Scholar
  3. 3.
    Hussain SM, Luedtke GS, Baker CJ, Schlievert PM, Leggiadro RJ. Invasive group B streptococcal disease in children beyond early infancy. Pediatr Infect Dis J. 1995;14:278–81.PubMedCrossRefGoogle Scholar
  4. 4.
    Guilbert J, Levy C, Cohen R; Bacterial meningitis group, Delacourt C, Renolleau S, Flamant C. Late and ultra late onset Streptococcus B meningitis: Clinical and bacteriological data over 6 years in France. Acta Paediatr. 2010;99:47–51.Google Scholar
  5. 5.
    Domingo P, Barquet N, Alvarez M, Coll P, Nava J, Garau J. Group B streptococcal meningitis in adults: Report of twelve cases and review. Clin Infect Dis. 1997;25:1180–7.PubMedCrossRefGoogle Scholar
  6. 6.
    Dalal BS, Lahiri A, Parel CC. Carriage rate of group B streptococci in pregnant women and evaluation of different isolation media. J Indian Med Assoc. 1998;96:360–1. 366.PubMedGoogle Scholar
  7. 7.
    Chaudhary U, Sabherwal U, Chugh TD. Prevalence of group B streptococci in obstetrical cases. Indian J Med Res. 1981;73:710–4.PubMedGoogle Scholar
  8. 8.
    Edmond KM, Kortsalioudaki C, Scott S, Schrag SJ, Zaidi AK, Cousens S. Group B streptococcal disease in infants aged younger than 3 months: Systematic review and meta-analysis. Lancet. 2012;379:547–56.PubMedCrossRefGoogle Scholar
  9. 9.
    Kuruvilla KA, Thomas N, Jesudasan MV, Jana AK. Neonatal Group B Streptococcal bacteraemia in India: Ten years’ experience. Acta Paediatr. 1999;88:1031–2.PubMedCrossRefGoogle Scholar
  10. 10.
    Chakrabarti P, Das BK, Kapil A. Application of 16S rDNA based seminested PCR for diagnosis of acute bacterial meningitis. Indian J Med Res. 2009;129:182–8.PubMedGoogle Scholar
  11. 11.
    Dmitriev A, Suvorov A, Shen AD, Yang YH. Clinical diagnosis of group B streptococci by scpB gene based PCR. Indian J Med Res. 2004;119:233–6.PubMedGoogle Scholar
  12. 12.
    Haffejee IE, Bhana RH, Coovadia YM, Hoosen AA, Marajh AV, Gouws E. Neonatal group B streptococcal infections in Indian (Asian) babies in South Africa. J Infect. 1991;22:225–31.PubMedCrossRefGoogle Scholar
  13. 13.
    Managoli S, Chaturvedi P, Vilhekar KY. Group B streptococcal meningitis in a 5-year-old boy. Indian J Pediatr. 2003;70:509–11.PubMedCrossRefGoogle Scholar
  14. 14.
    Phares CR, Lynfield R, Farley MM, Mohle-Boetani J, Harrison LH, Petit S, et al; Active bacterial core surveillance/Emerging infections program network. Epidemiology of invasive group B streptococcal disease in the United States, 1999–2005. JAMA. 2008;299:2056–65.Google Scholar
  15. 15.
    Cho HK, Lee H, Kang JH, Kim KN, Kim DS, Kim YK, et al. The causative organisms of bacterial meningitis in Korean children in 1996–2005. J Korean Med Sci. 2010;25:895–9.PubMedCentralPubMedCrossRefGoogle Scholar
  16. 16.
    Miyairi I, Causey KT, DeVincenzo JP, Buckingham SC. Group B streptococcal ventriculitis: A report of three cases and literature review. Pediatr Neurol. 2006;34:395–9.PubMedCrossRefGoogle Scholar

Copyright information

© Dr. K C Chaudhuri Foundation 2013

Authors and Affiliations

  • Shalini Dwivedi
    • 1
  • Bimal K. Das
    • 1
  • Satinder Aneja
    • 2
  • Suvasini Sharma
    • 2
  • Mona K. Chaturvedi
    • 3
  • Geoff Kahn
    • 4
  • Sean P. Fitzwater
    • 5
  • Aruna Chandran
    • 6
  • Nitya Wadhwa
    • 7
  • Shinjini Bhatnagar
    • 7
  1. 1.Department of MicrobiologyAll India Institute of Medical SciencesNew DelhiIndia
  2. 2.Department of PediatricsLady Hardinge Medical College and Associated Kalawati Saran Children’s HospitalNew DelhiIndia
  3. 3.Department of PediatricsAll India Institute of Medical SciencesNew DelhiIndia
  4. 4.Johns Hopkins School of Public HealthBaltimoreUSA
  5. 5.Department of International HealthJohns Hopkins School of Public HealthBaltimoreUSA
  6. 6.Department of International Health and PediatricsJohns Hopkins School of Public HealthBaltimoreUSA
  7. 7.Pediatric Biology CentreTranslational Health Science & Technology InstituteGurgaonIndia

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