The Indian Journal of Pediatrics

, Volume 80, Issue 4, pp 343–344

Dexmedetomidine in a Child with Methylphenidate Intoxication

  • Dayanand N. Bagdure
  • Girija R. Bhoite
  • Pamela D Reiter
  • Emily L. Dobyns
Clinical Brief


Methylphenidate intoxication, due to accidental ingestion, is a common occurrence in pediatrics. Symptoms of extreme agitation are typically controlled with benzodiazepines or barbiturates. There is, however, a legitimate risk of mechanical ventilation due to respiratory depression with increasing doses of benzodiazepines. The authors describe a case of 7-y-old girl with methylphenidate toxicity where dexmedetomidine was successfully used to manage agitation and cardiovascular stimulation without respiratory compromise.


Intoxication Psychostimulant Management 


  1. 1.
    Scharman EJ, Erdman AR, Cobaugh DJ, et al; American Association of Poison Control Centers. Methylphenidate poisoning: An evidence-based consensus guideline for out-of-hospital management. Clin Toxicol (Phila). 2007;45:737–52.CrossRefGoogle Scholar
  2. 2.
    Klein-Schwartz W. Pediatric methylphenidate exposures: 7-year experience of poison centers in the United States. Clin Pediatr (Phila). 2003;42:159–64.CrossRefGoogle Scholar
  3. 3.
    Volkow ND, Wang GJ, Fowler JS, et al. Dopamine transporter occupancies in the human brain induced by therapeutic doses of oral methylphenidate. Am J Psychiatry. 1998;155:1325–31.PubMedGoogle Scholar
  4. 4.
    Solanto MV. Neuropsychopharmacological mechanisms of stimulant drug action in attention-deficit hyperactivity disorder: A review and integration. Behav Brain Res. 1998;94:127–52.PubMedCrossRefGoogle Scholar
  5. 5.
    LoVecchio F, Ozimek J, Sawyers B, Thole D. Outcomes after accidental pediatric ingestions of (dextro) amphetamine and methylphenidate. Am J Emerg Med. 2009;27:933–4.PubMedCrossRefGoogle Scholar
  6. 6.
    Klein-Schwartz W, McGrath J. Poison centers’ experience with methylphenidate abuse in pre-teens and adolescents. J Am Acad Child Adolesc Psychiatry. 2003;42:288–94.PubMedCrossRefGoogle Scholar

Copyright information

© Dr. K C Chaudhuri Foundation 2012

Authors and Affiliations

  • Dayanand N. Bagdure
    • 1
  • Girija R. Bhoite
    • 2
  • Pamela D Reiter
    • 3
  • Emily L. Dobyns
    • 1
  1. 1.Pediatric Intensive Care Unit, Section of Critical Care MedicineChildren’s Hospital ColoradoAuroraUSA
  2. 2.Union Memorial HospitalBaltimoreUSA
  3. 3.Department of Pharmacy, Center for Pediatric MedicineChildren’s Hospital, ColoradoAuroraUSA

Personalised recommendations