The Indian Journal of Pediatrics

, Volume 79, Issue 4, pp 478–482

Efficacy and Safety of Saccharomyces boulardii in Acute Childhood Diarrhea: A Double Blind Randomised Controlled Trial

  • Musheer Riaz
  • Seema Alam
  • Abida Malik
  • S. Manazir Ali
Original Article



To see the efficacy and safety of 250 mg of Saccharomyces boulardii twice daily for 5 d in acute childhood diarrhea.


Children aged between 3 mo and 59 mo with acute onset diarrhea (of less than 48 h) admitted in DTTU (diarrhea treatment and training unit) were included and those with clinical evidence of severe malnutrition, systemic infection, encephalopathy and/or convulsion, electrolyte imbalance, invasive diarrhea or previous use of any probiotics were excluded from the study. Those included randomly were given either a placebo or Saccharomyces boullardi (SB) in identical packets mixed with puffed rice powder.


Mean post intervention duration of diarrhea was significantly (95% CI = −28.13 to −5.43) shorter in SB group (52.08 ± 24.57 h) as compared to placebo group (64.04 ± 30.43 h). The time of appearance of first semi formed stool in SB group (39.48 ± 23.09 h) was significantly (95% CI −25.4 to −3.87) shorter than the placebo group (54.13 ± 28.21 h). No statistically significant difference was found in rest of the parameters.


There is initial evidence available that SB may have a therapeutic role in the management of acute childhood diarrhea.


Acute diarrhea Probiotics Saccharomyces boularrdii Therapeutic role 

Copyright information

© Dr. K C Chaudhuri Foundation 2011

Authors and Affiliations

  • Musheer Riaz
    • 1
  • Seema Alam
    • 2
  • Abida Malik
    • 3
  • S. Manazir Ali
    • 1
  1. 1.Department of PediatricsJawaharlal Nehru Medical College, AMUAligarhIndia
  2. 2.Department of Pediatric HepatologyInstitute of Liver and Biliary SciencesNew DelhiIndia
  3. 3.Department of MicrobiologyJawaharlal Nehru Medical College, AMUAligarhIndia

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