The Indian Journal of Pediatrics

, 78:1407

Glucose Tolerance in Overweight and Obese North Indian Adolescents

  • Minoo Sharma
  • Urmil Gupta
  • Anita Padam
  • Parveen Bhardwaj
  • Neelam Grover
Clinical Brief

Abstract

The present analytic study was planned to study the impact of overweight and obesity on glucose tolerance in adolescents. Thirty overweight (BMI analogue ≥ 25–29.9 kg/m2) and 30 obese (BMI analogue ≥ 30 kg/m2) adolescents were included as cases and 30 healthy age and sex matched adolescents comprised the control group. All the study participants were subjected to oral glucose tolerance test (OGTT) as a measure of glucose tolerance.Means of fasting blood glucose levels in normal, overweight and obese groups were 84.5 mg/dl, 86.7 mg/dl and 94.8 mg/dl respectively. Means of two hourly blood glucose levels in normal, overweight and obese groups were 105.8 mg/dl, 117 mg/dl and 127.1 mg/dl respectively. Oral Glucose tolerance test (OGTT) was normal in all the participants from control group but was impaired in four overweight adolescents. In obese group, OGTT was impaired in eight subjects and one obese child had fasting and 2 hourly blood glucose levels in diabetic range.

Keywords

Obesity Overweight Adolescents Indian OGTT 

References

  1. 1.
    Styne DM. Childhood and adolescent obesity: prevalence and significance. PCNA. 2001;48:823–54.CrossRefGoogle Scholar
  2. 2.
    Bhave S, Bavdekar A, Otiv M. IAP national task force for childhood prevention of adult diseases: childhood obesity. Indian Pediatr. 2004;41:559–75.PubMedGoogle Scholar
  3. 3.
    Cole TJ, Bellizzi MC, Flegal KM, Dietz WH. Establishing a standard definition for child overweight and obesity worldwide international survey. BMJ. 2000;320:1240–3.PubMedCrossRefGoogle Scholar
  4. 4.
    Weiss R, Taksali SE, Tamborlane WV, Burgert TS, Savoye M, Caprio S. Predictors of changes in Glucose Tolerance status in obese youth. Diabetes Care. 2005;28:902–9.PubMedCrossRefGoogle Scholar
  5. 5.
    Plourde G. Impact of obesity on glucose and lipid profiles in adolescents at different age groups in relation to adulthood. BMC Fam Pract. 2002;3:18.PubMedCrossRefGoogle Scholar
  6. 6.
    American Diabetes Association. Type 2 diabetes in children and adolescents. Diabetes Care. 2000;23:381–9.CrossRefGoogle Scholar
  7. 7.
    Brickman WJ, Holland JS, Silverman BL. Prevalence of postprandial hyperglycemia in adolescents. Diabetes Care. 2002;25:1887–8.PubMedCrossRefGoogle Scholar
  8. 8.
    Sinha R, Fisch G, Teague B, et al. Prevalence of impaired glucose tolerance among children and adolescents with marked obesity. N Engl J Med. 2002;346:802–10.PubMedCrossRefGoogle Scholar
  9. 9.
    Kaur S, Kapil U. Impaired glucose tolerance and diabetes mellitus in obese children. Indian Pediatr. 2010;47:362–3.PubMedCrossRefGoogle Scholar
  10. 10.
    Chathurvedi D, Khagawat R, Kulshrestha B, et al. Type 2 diabetes increases risk for obesity among subsequent generations. Diabetes Technol Ther. 2009;11:393–8.PubMedCrossRefGoogle Scholar

Copyright information

© Dr. K C Chaudhuri Foundation 2011

Authors and Affiliations

  • Minoo Sharma
    • 1
  • Urmil Gupta
    • 1
  • Anita Padam
    • 1
  • Parveen Bhardwaj
    • 2
    • 3
  • Neelam Grover
    • 2
  1. 1.Department of PhysiologyIndira Gandhi Medical CollegeShimlaIndia
  2. 2.Department of PediatricsIndira Gandhi Medical CollegeShimlaIndia
  3. 3.ShimlaIndia

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