The Indian Journal of Pediatrics

, Volume 78, Issue 2, pp 234–236 | Cite as

Bilateral Optic Neuritis in Pediatric Systemic Lupus Erythematosus with Antiphospholipid Antibody Syndrome

  • Soumya Patra
  • Sriram Krishnamurthy
  • Anju Seth
  • Sarita Beri
  • Satinder Aneja
Clinical Brief

Abstract

Bilateral optic neuritis is an extremely uncommon complication of pediatric systemic lupus erythematosus and sporadic cases are reported in the literature. The authors describe an 11-yr-old girl who presented with fever and progressively increasing pallor for 4 months, headache for 7 days, severe anemia and hepatosplenomegaly. Soon after admission, she developed rapid deterioration of vision, worsening to no perception of light with afferent pupillary defect. Fundoscopy showed bilateral optic neuritis. Investigations revealed autoimmune hemolytic anemia and thrombocytopenia. Anti-dsDNA and anti-phospholipid antibodies were positive. Magnetic resonance venography showed multiple thrombi in the cerebral venous sinuses, for which anticoagulant therapy was initiated. She was managed with intravenous methylprednisolone followed by cyclophosphamide pulse therapy for 6 months along with oral prednisolone. Though she went into remission, visual outcome has been dismal, with development of bilateral optic atrophy, and absence of perception of light.

Keywords

Optic neuritis Autoimmune hemolytic anemia Systemic lupus erythematosus Anti-phospholipid antibody syndrome 

Notes

Conflict of interest

None stated.

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Copyright information

© Dr. K C Chaudhuri Foundation 2010

Authors and Affiliations

  • Soumya Patra
    • 1
  • Sriram Krishnamurthy
    • 1
  • Anju Seth
    • 1
  • Sarita Beri
    • 2
  • Satinder Aneja
    • 1
  1. 1.Department of PediatricsLady Hardinge Medical College and associated Kalawati Saran Children’s HospitalNew DelhiIndia
  2. 2.Department of OphthalmologyLady Hardinge Medical CollegeNew DelhiIndia

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