The Indian Journal of Pediatrics

, Volume 77, Issue 11, pp 1261–1265 | Cite as

Utility of ApoB/ApoA1 Ratio for the Prediction of Cardiovascular Risk in Children with Metabolic Syndrome

  • S. Savas Erdeve
  • E. Simsek
  • Yildiz Dallar
  • Zeynep Biyikli
Original Article

Abstract

Objective

To assess whether apoB/apoA1 ratio is associated or not with metabolic syndrome in obese children.

Methods

A 198 obese children and 41 healthy control subjects were enrolled in a cross-sectional study. The apoB/apoA1 ratio and other metabolic sydrome components in obese children with/without metabolic syndrome were compared to healthy controls.

Results

The apoA1 level did not show significant difference (p = 0.664) but apoB level (p = 0.000) and apoB/apoA1 ratio (p = 0.001) were significantly higher in obese group than in control group. Also, the apoB/apoA1 ratio was significantly higher in obese children with metabolic syndrome when compared to obese children without metabolic syndrome (p = 0.007) and showed positive correlation with triglyceride (r = 0.404, p = 0.000) and negative correlation with high-density lipoprotein cholesterol (r = −0.593, p = 0.000).

Conclusions

The apoB/apoA1 ratio is associated with metabolic syndrome in obese children. An elevated apoB/apoA1 ratio may constitute an important feature of the metabolic syndrome. There is a need for long term follow-up studies concerning cardiovascular risk in obese children with metabolic syndrome and high apoB/apoA1 ratio.

Keywords

Apolipoprotein AI Apolipoprotein B Apolipoprotein B/Apolipoprotein AI ratio Child Metabolic syndrome 

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Copyright information

© Dr. K C Chaudhuri Foundation 2010

Authors and Affiliations

  • S. Savas Erdeve
    • 1
  • E. Simsek
    • 2
  • Yildiz Dallar
    • 3
  • Zeynep Biyikli
    • 4
  1. 1.Department of Pediatrics, Division of Pediatric EndocrinologyAnkara University School of MedicineAnkaraTurkey
  2. 2.Division of Pediatric Endocrinology, Department of PediatricsOsmangazi University School of MedicineKonuralp-DuzceTurkey
  3. 3.Department of PediatricsAnkara Research and Training HospitalAnkaraTurkey
  4. 4.Department of BiostatisticsAnkara University School of MedicineAnkaraTurkey

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