The Indian Journal of Pediatrics

, Volume 77, Issue 10, pp 1173–1181 | Cite as

Fevers and the Rheumatologist

Symposium on Pediatric Rheumatology-II


Fevers in children are mainly due to infection, malignancy or inflammatory conditions. Rheumatologists have an important role in the care of inflammatory conditions, many of which are associated with fevers. Seven conditions, the hereditary recurrent fever syndromes, have been defined with the presenting symptom of recurring fever, and for which mutation of a single gene has been defined: Chronic infantile neurological articular syndrome (CINCA), Familial cold autoinflammatory syndrome (FACS), Familial Mediterranean fever (FMF), hyperimmunoglobulinemia D (HIDS), Muckle-Wells syndrome (MWS), Pyogenic sterile arthritis and Pyoderma gangrenosum (PAPA) and Tumour necrosis factor receptor-associated periodic syndrome (TRAPS) . These conditions will be discussed in detail in regard to how they fit into the wider picture of pediatric rheumatological conditions, how the diagnoses may be established and the current recommended treatments for each condition.


Hereditary recurrent fever syndromes Cryopyrinopathies 


CINCA syndrome

Chronic Infantile Neurological Articular Syndrome


Familial Cold Autoinflammatory Syndrome


Familial Mediterranean Fever


Hyperimmunoglobulinemia D Syndrome


Muckle-Wells Syndrome


Neonatal-Onset Multi-System Inflammatory Disease


Pyogenic Sterile Arthritis, Pyoderma Gangrenosum and Acne


Periodic Fever, Aphthous Ulcers, Pharyngitis and Cervical Adenitis


Tumour Necrosis Factor Receptor-Associated Periodic Syndrome


Systemic Lupus Erythematosus


Juvenile Idiopathic Arthritis




Mixed Connective Tissue Disease


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Copyright information

© Dr. K C Chaudhuri Foundation 2010

Authors and Affiliations

  1. 1.School of Paediatrics and Child HealthUniversity of Western Australia, c/- Princess Margaret Hospital for ChildrenPerthAustralia

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