The Indian Journal of Pediatrics

, Volume 78, Issue 1, pp 65–72

Iron Deficiency: Beyond Anemia

Symposium On Nutritional Anemia - II

DOI: 10.1007/s12098-010-0129-7

Cite this article as:
Yadav, D. & Chandra, J. Indian J Pediatr (2011) 78: 65. doi:10.1007/s12098-010-0129-7


Iron deficiency is the most common nutritional disorder affecting at least one third of world’s population. Though anemia is common manifestation of iron deficiency, other effects of iron deficiency on various tissues, organs and systems are usually under recognized. Impaired brain development and cognitive, behavioural and psychomotor impairment are most worrisome manifestations of iron deficiency. Studies have demonstrated that some of these changes occurring during period of brain growth spurt (<2 years age) may be irreversible. Association of iron deficiency with febrile seizures, pica, breath holding spells, restless leg syndrome and thrombosis is increasingly being recognized. Impaired cell-mediated immunity and bactericidal function are generally noted in iron-deficient persons; however, the findings are inconsistent. Despite proven reversible functional immunological defects in vitro studies, a clinically important relationship between states of iron deficiency and susceptibility to infections remains controversial. Studies from malaria endemic regions have reported increased incidence of malaria in association with iron supplementation. These and some other aspects of iron deficiency are reviewed in this article.


Iron deficiency anemia (IDA) Cognition Breath holding spells (BHS) Pica Febrile seizure Thrombosis Restless leg syndrome Infections 

Copyright information

© Dr. K C Chaudhuri Foundation 2010

Authors and Affiliations

  1. 1.Department of PediatricsKalawati Saran Children’s Hospital and Lady Hardinge Medical CollegeNew DelhiIndia
  2. 2.Lady Hardinge Medical CollegeNew DelhiIndia

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