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The Indian Journal of Pediatrics

, Volume 77, Issue 7, pp 789–793 | Cite as

Iron deficiency and infection

  • Vishal KumarEmail author
  • V. P. Choudhry
Symposium on Nutritional Anemia

Abstract

Iron deficiency is the most common micronutrient deficiency in the world. Children, particularly infants living in developing countries are highly vulnerable to infectious diseases. Therefore, understanding the relationship between iron deficiency and infection is of great importance. Iron deficiency is associated with impairment of innate (natural) immunity and cell mediated immunity, thereby contributing to increased risk of infections. The iron acquisition by the microbes and their virulence is determined by various host and microbial mechanisms. Altering these mechanisms might provide modes of future therapy for infectious diseases.

Key words

Iron deficiency Immunity Infection 

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References

  1. 1.
    Cunningham-Rundles S. Effects of nutritional status on immunological function. Am J Clin Nutr 1982; 35:S1202–S1210.Google Scholar
  2. 2.
    Chandra RK. Reduced bactericidal capacity of polymorphs in iron deficiency. Arch Dis Child 1973; 48:864–866.CrossRefPubMedGoogle Scholar
  3. 3.
    Bhaskaram C, Reddy V. Cell mediated immunity in iron- and vitamin- deficient children. Br Med J 1975; 3:522–522.CrossRefPubMedGoogle Scholar
  4. 4.
    Kochan I. The role of iron in bacterial infections with special consideration of host-tubercle bacillus interaction. Curr Top Microbiol Immunol 1973; 60:1–30.PubMedGoogle Scholar
  5. 5.
    Beard JL. Iron biology in immune function, muscle metabolism and neuronal functioning. J Nutr 2001; 131:568S–580S.PubMedGoogle Scholar
  6. 6.
    Spear AT, Sherman AR. Iron deficiency alters DMBA-induced tumor burden and natural killer cell cytotoxicity in rats. J Nutr 1992; 122:46–55.PubMedGoogle Scholar
  7. 7.
    Oppenheimer SJ. Iron and its relation to immunity and infectious disease. J Nutr 2001; 131:616S–635S.PubMedGoogle Scholar
  8. 8.
    Markel TA, Crisotomo PR, Wang M et al. The struggle for iron: gastrointestinal microbes modulate the host immune response during infection. J Leukoc Biol 2007; 81:393–400.CrossRefPubMedGoogle Scholar
  9. 9.
    Hallquist NA, McNeil LK, Lockwood JF, Sherman AR. Maternal-iron-deficiency effects on peritoneal macrophage and peritoneal natural-killer-cell cytotoxicity in rat pups. Am J Clin Nutr 1992; 55:741–746.PubMedGoogle Scholar
  10. 10.
    Bagchi K, Mohanram M, Reddy V. Humoral immune response in children with iron-deficiency anaemia. Br Med J 1980; 280:1249–1251.CrossRefPubMedGoogle Scholar
  11. 11.
    Svoboda M, Nechvatalova K, Krejci J, Drabek J, Ficek R, Faldyna M. The absence of iron deficiency effect on the humoral immune response of piglets to tetanus toxoid. Veterinarni Medicina 2007; 52:179–185.Google Scholar
  12. 12.
    Murray MJ, Murray AB, Murray MB, Murray CJ. The adverse effect of iron repletion on the course of certain infections. Br Med J 1978; 2:1113–1115.CrossRefPubMedGoogle Scholar
  13. 13.
    Oppenheimer SJ, Gibson FD, Macfarlane SB et al. Iron supplementation increases prevalence and effects of malaria: report on clinical studies in Papua New Guinea. Trans R Soc Trop Med Hyg 1986; 80:603–612.CrossRefPubMedGoogle Scholar
  14. 14.
    Bullen J, Griffiths E, Rogers H, Ward G. Sepsis: the critical role of iron. Microbes Infect 2000; 2:409–415.CrossRefPubMedGoogle Scholar
  15. 15.
    Ahluwalia N, Sun J, Krause D, Mastro A, Handte G. Immune function is impaired in iron-deficient, homebound, older women. Am J Clin Nutr 2004; 79:516–521.PubMedGoogle Scholar
  16. 16.
    Ekiz C, Agaoglu L, Karakas Z, Gurel N, Yalcin I. The effect of iron deficiency anemia on the function of immune system. Hematol J 2005; 5:579–583.CrossRefPubMedGoogle Scholar
  17. 17.
    Snow RW, Byass P, Shenton FC, Greenwood BM. The relationship between anthropometric measurements and measurements of iron status and susceptibility to malaria in Gambian children. Trans R Soc Trop Med Hyg 1991; 85:584–589.CrossRefPubMedGoogle Scholar
  18. 18.
    Oppenheimer SJ, Hill AV, Gibson FD, Macfarlane SB, Moody JB, Pringle J. The interaction of alpha thalassaemia with malaria. Trans R Soc Trop Med Hyg 1987; 81:322–326.CrossRefPubMedGoogle Scholar
  19. 19.
    Higgs JM, Wells RS. Chronic muco-cutaneous candidiasis: new approaches to treatment. Br J Dermatol 1973; 89:179–190.PubMedGoogle Scholar
  20. 20.
    Weijmer MC, Neering H, Welten C. Preliminary report: furunculosis and hyporferraemia. Lancet 1990; 336:464–466.CrossRefPubMedGoogle Scholar
  21. 21.
    Harju E. Empty iron stores as a significant risk factor in abdominal surgery. J Parenter Enteral Nutr 1988; 12:282–285.CrossRefGoogle Scholar
  22. 22.
    MacKay HM. Anaemia in infancy; its prevalence and prevention. Arch Dis Child 1928; 3:117–147.CrossRefGoogle Scholar
  23. 23.
    Andelman MB, Sered BR. Utilization of dietary iron by term infants. A study of 1,048 infants from a low socioeconomic population. Am J Dis Child 1966; 111:45–55.PubMedGoogle Scholar
  24. 24.
    Cantwell RJ. Iron deficiency anemia of infancy: some clinical principles illustrated by the response of Maori infants to neonatal parenteral iron administration. Clin Pediatr 1972; 11:443–449.CrossRefGoogle Scholar
  25. 25.
    Barry DM, Reeve AW. Increased incidence of gram-negative neonatal sepsis with intramuscular iron administration. Pediatrics 1977; 60:908–912.PubMedGoogle Scholar
  26. 26.
    James JA, Combes M. Iron deficiency in the premature infant: Significance and prevention by the intramuscular administration of iron-dextran. Pediatrics 1960; 26:368–374.PubMedGoogle Scholar
  27. 27.
    Berger J, Dyck JL, Galan P et al. Effect of daily iron supplementation on iron status, cell-mediated immunity, and incidence of infections in 6–36 month old Togolese children. Eur J Clin Nutr 2000; 54:29–35.CrossRefPubMedGoogle Scholar
  28. 28.
    Gera T, Sachdev HP. Effect of iron supplementation on incidence of infectious illness in children: systematic review. Br Med J 2002; 325:1142–1144.CrossRefGoogle Scholar
  29. 29.
    Tielsch JM, Khatry S, Stoltzfus RJ et al. Effect of routine prophylactic supplementation with iron and folic acid on preschool child mortality in southern Nepal: community-based, cluster-randomised, placebo-controlled trial. Lancet 2006; 367:144–152.CrossRefPubMedGoogle Scholar
  30. 30.
    Sazawal S, Black RE, Ramsan M et al. Effect of routine prophylactic supplementation with iron and folic acid on admission to hospital and mortality in preschool children in a high malaria transmission setting: community-based, randomised placebo-controlled trial. Lancet 2006; 367:133–143.CrossRefPubMedGoogle Scholar
  31. 31.
    Weinberg ED. Iron availability and infection. Biochim Biophys Acta 2009; 1790:600–605.PubMedGoogle Scholar
  32. 32.
    Beaumont C, Delaby C. Recycling iron in normal and pathological states. Semin Hematol 2009; 46:328–338.CrossRefPubMedGoogle Scholar
  33. 33.
    Ganz T, Nemeth E. Iron sequestration and anemia of inflammation. Semin Hematol 2009; 46:387–393.CrossRefPubMedGoogle Scholar
  34. 34.
    Jurado RL. Iron, infections, and anemia of inflammation. Clin Infect Dis 1997; 25:888–895.CrossRefPubMedGoogle Scholar
  35. 35.
    Nishimoto N, Kanakura Y, Aozasa K et al. Humanized antiinterleukin-6 receptor antibody treatment of multicentric Castleman disease. Blood 2005; 106: 2627–2632.CrossRefPubMedGoogle Scholar
  36. 36.
    Kawabata H, Tomosugi N, Kanda J, Tanaka Y, Yoshizaki K, Uchiyama T. Anti-interleukin 6 receptor antibody tocilizumab reduces the level of serum hepcidin in patients with multicentric Castleman’s disease. Haematologica 2007; 92:857–858.CrossRefPubMedGoogle Scholar

Copyright information

© Dr. K C Chaudhuri Foundation 2010

Authors and Affiliations

  1. 1.Department of PediatricsChacha Nehru Bal ChikitsalyaDelhiIndia
  2. 2.Department of Hematology, Paras Hospital, GurgaonSun Flag Pahuja Centre for Blood DisordersFaridabadIndia
  3. 3.Chacha Nehru Bal ChikitsalyaDelhiIndia

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