Iron deficiency and infection
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Iron deficiency is the most common micronutrient deficiency in the world. Children, particularly infants living in developing countries are highly vulnerable to infectious diseases. Therefore, understanding the relationship between iron deficiency and infection is of great importance. Iron deficiency is associated with impairment of innate (natural) immunity and cell mediated immunity, thereby contributing to increased risk of infections. The iron acquisition by the microbes and their virulence is determined by various host and microbial mechanisms. Altering these mechanisms might provide modes of future therapy for infectious diseases.
Key wordsIron deficiency Immunity Infection
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- 1.Cunningham-Rundles S. Effects of nutritional status on immunological function. Am J Clin Nutr 1982; 35:S1202–S1210.Google Scholar
- 11.Svoboda M, Nechvatalova K, Krejci J, Drabek J, Ficek R, Faldyna M. The absence of iron deficiency effect on the humoral immune response of piglets to tetanus toxoid. Veterinarni Medicina 2007; 52:179–185.Google Scholar
- 30.Sazawal S, Black RE, Ramsan M et al. Effect of routine prophylactic supplementation with iron and folic acid on admission to hospital and mortality in preschool children in a high malaria transmission setting: community-based, randomised placebo-controlled trial. Lancet 2006; 367:133–143.CrossRefPubMedGoogle Scholar