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Ovarian tumors with elevated CA-125 levels and severe juvenile hypothyroidism: A need for increased awareness

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A 15-yr-old girl presented with bilateral gross ovarian tumors, clinical features of long-standing unrecognized hypothyroidism and markedly elevated CA-125 levels. Ovarian resection was avoided, as the presentation was consistent with the Van Wyk and Grumbach syndrome; and the patient was treated with replacement of thyroid hormone. Regression of the ovarian tumors occurred 6 months after initiation of the treatment. The authors emphasise the need for increased awareness and screening for hypothyroidism in patients with ovarian tumors, in order to prevent inadvertent operative interventions.

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Correspondence to Sriram Krishnamurthy.

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Krishnamurthy, S., Seth, A., Puri, A. et al. Ovarian tumors with elevated CA-125 levels and severe juvenile hypothyroidism: A need for increased awareness. Indian J Pediatr 77, 693–694 (2010). https://doi.org/10.1007/s12098-010-0081-6

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Key words

  • Ovarian tumors
  • Hypothyroidism
  • Thyroid hormone