The Indian Journal of Pediatrics

, Volume 76, Issue 11, pp 1169–1172

Transient neonatal diabetes due to activating mutation in the ABCC8 gene encoding SUR1

  • C. M. Batra
  • Nomeeta Gupta
  • Gurdeep Atwal
  • Vimal Gupta
Clinical Brief

DOI: 10.1007/s12098-009-0222-y

Cite this article as:
Batra, C.M., Gupta, N., Atwal, G. et al. Indian J Pediatr (2009) 76: 1169. doi:10.1007/s12098-009-0222-y

Abstract

We report a 2 month male child presenting with diabetic ketoacidosis (DKA) and seizures treated with intravenous fluids and intravenous insulin infusion till the ketoacidosis was reversed, thereafter responding well to sulphonylureas and at age of 13 months going into complete remission. At age of 11 months developmental delay in the form of negative neck holding and inability to sit without support was seen. The child is 3 years of age now, euglycemic without any insulin or oral hypoglycemic agents but has severe developmental delay. Genetic analysis was negative for mutations of KCNJ11, 6q24, Glucokinase and IPF-1 genes. A mutation R1183W was found in the ABCC8 gene encoding SUR1, which was the cause of neonatal diabetes in this case.

Copyright information

© Dr. K C Chaudhuri Foundation 2009

Authors and Affiliations

  • C. M. Batra
    • 1
  • Nomeeta Gupta
    • 2
  • Gurdeep Atwal
    • 2
  • Vimal Gupta
    • 1
  1. 1.Department of EndocrinologyBatra Hospital and Medical Research CentreNew DelhiIndia
  2. 2.Department of PediatricsBatra Hospital and Medical Research CentreNew DelhiIndia

Personalised recommendations