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The Indian Journal of Pediatrics

, Volume 76, Issue 2, pp 177–184 | Cite as

Advances in management of Thalassemia

  • M.B. AgarwalEmail author
Special Article

Abstract

Thalassemias represent the most common single-gene disorder causing a major public health problem in India. Thalassemia and hemoglobinopathies probably developed over 7000 years ago as a defense against malaria. In simple terms, thalassemia is caused by a mutation in either the â-globin chain or the á-globin chain which combine equally in red cells to form hemoglobin. These mutations lead to varying degree of anemia resulting into thalassemia minor, intermedia or major. Present write up relates to advances in the management of â-thalassemia major.

Key words

Thalassemias Hemoglobinopathies Anemia Single-gene disorder Management 

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Copyright information

© Dr. K C Chaudhuri Foundation 2009

Authors and Affiliations

  1. 1.Department of HematologyBombay Hospital Institute of Medical SciencesMumbaiIndia

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