The Indian Journal of Pediatrics

, Volume 76, Issue 1, pp 83–85 | Cite as

Adverse events associated with neonatal exchange transfusion for hyperbilirubinemia

Clinical Brief


To estimate the incidence of blood exchange and determine causes and complication of blood exchange and identify strategies for risk reduction of Kernicterus in newborn with jaundice. From march 2004 to march 2006 in neonatal Department in children hospital, medical center Tehran, Iran,346 neonates were admitted as neinatal jaundice without sign and symptoms of infections. We identified causes and complications of exchange. Of 346 infants with jaundice who received phototherapy. 50, 14.45 percent cases underwent exchange transfusion with mean age 9.38+5.75 days. The mean total Serum billirubin level was 29.39+6.13mg/dl. ABO incompatibility was the most common cause for hyperbillirubinemia.the incidence of apnea was 12% there was no direct death from exchange transfusion. To make payment women aware to cbserve jaundice regularly after birth of their child and short breast feeding to control dehydretion.

Key words

Adverse events Neonatal exchange transfusion Hyperbilirubinemia 



Statistical package for the social sciences


Red blood cell


Complete blood count


Peripheral blood smear


Glucose 6 phosphate dehydrogenase deficiency


Specific gravity


Necrotizing enterocolitis


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  1. 1.
    Alexandra Brito M, Silva RF, Brites D. Bilirubin toxicity to human erythrocytes: a review. Clin Chim Acta 2006; 374: 46–56.CrossRefGoogle Scholar
  2. 2.
    Maisels MJ, Kring E. The contribution of hemolysis to early jaundice in normal newborns. Pediatrics 2006; 118: 276–279.CrossRefPubMedGoogle Scholar
  3. 3.
    Barbara J Stoll. Jaundice and Hyperbilirubinemia in the Newborn-Kernicterus. In Richard E. Behram, Robert M. Kleigman, Hal B. Jenson, eds. Nelson Textbook of Pediatrics, 17th ed. Saunders, 2004; 592–599.Google Scholar
  4. 4.
    Sgro M, Campbell D, Shah V. Incidence and causes of severe neonatal hyperbilirubinemia in Canada. CMAJ 200612; 175: 587–590.PubMedGoogle Scholar
  5. 5.
    Haung MJ, Kua KE, Teng HC, Tang KS, Weng HW, Huang CS. Risk factors for severe hyperbilirubinemia in neonates. Pediatric Research 2004; 56: 682–689.CrossRefGoogle Scholar
  6. 6.
    Gourley GR. Another risk factor for neonatal hyperbilirubinemia. J Pediatr Gastroenterol Nutr 2005; 40: 388–389.CrossRefPubMedGoogle Scholar
  7. 7.
    Chen WX, Wong VC, Wong KY. Neurodevelopmental outcome of severe neonatal hemolytic hyperbilirubinemia. J Child Neurol 2006; 21: 474–479.PubMedGoogle Scholar
  8. 8.
    Lo YS, Lu CC, Chen LY, Tsai LT. Clinical studies of neonatal hyperbilirubinemia treated with blood exchange transfusion. Gaoxiong Yi Xue Ke Xue Za Zhi 1990; 6: 556–564.PubMedGoogle Scholar
  9. 9.
    Weisz B, Belson A, Milbauer B, Reif S. Complications of exchange transfusion in term and preterm newborns. Harefuah 1996; 130: 170–223PubMedGoogle Scholar
  10. 10.
    Tan KL, Phua KB, Ang PL. The mortality of exchange transfusions. Med J A ust 1976; 1: 473–476.Google Scholar
  11. 11.
    Tioseco JA, Aly H, Milner J, Patel K, EI-Mohandes AA. Does gender affect neonatal hyperbilirubinemia in low-birthweight infants? Pediatr Crit Care Med 2005; 6: 171–174.CrossRefPubMedGoogle Scholar
  12. 12.
    Kaplan M, Hammerman C. Glucose -6-phosphate dehydrogenase deficiency: a hidden risk for kernicterus. Semin Perinatol 2004; 28: 356–364.CrossRefPubMedGoogle Scholar
  13. 13.
    Patra K, Storfer-Isser A, Siner B, Moore J, Hack M. Adverse events associated with neonatal exchange transfusion in the 1990s. J Pediatr 2004; 144: 626–631.CrossRefPubMedGoogle Scholar
  14. 14.
    Ogunfowora OB, Adefuye PO, Fetuga MB. What do expectant mothers know about neonatal jaundice? International Electronic Journal of Health Education 2006; 9:134–140.Google Scholar

Copyright information

© Dr. K C Chaudhuri Foundation 2009

Authors and Affiliations

  • Sh. Behjati
    • 1
  • S. Sagheb
    • 1
    • 2
  • S. Aryasepehr
    • 1
  • B. Yaghmai
    • 1
  1. 1.Neonatal DepartmentChildren Hospital Medical CenterTehranIran
  2. 2.Resident of Pediatrics, Neonatal departmentChildren hospital Medical centerTehranIran

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