The Indian Journal of Pediatrics

, Volume 75, Issue 12, pp 1231–1235

Intravenous immune globulin versus intravenous anti-D immune globulin for the treatment of acute immune thrombocytopenic purpura

  • Elham Shahgholi
  • Parvaneh Vosough
  • Kambiz Sotoudeh
  • Khadijeh Arjomandi
  • Shahla Ansari
  • Soraya Salehi
  • Mohammad Faranoush
  • Mohammad Ali Ehsani
Original Article

DOI: 10.1007/s12098-008-0243-y

Cite this article as:
Shahgholi, E., Vosough, P., Sotoudeh, K. et al. Indian J Pediatr (2008) 75: 1231. doi:10.1007/s12098-008-0243-y

Abstract

Objective

The purpose of this study was to compare the efficacy and side effects of intravenous immunoglobulin (IVIG) with intravenous anti-D immunoglobulin for treatment of newly diagnosed acute childhood Idiopathic thrombocytopenic purpura (ITP).

Methods

Children (6 months to 14 years) with newly diagnosed acute ITP and platelet count below 20,000/ μL were randomized to receive single dose intravenous 75 μg/kg anti-D or 1g/kg IVIG for two consecutive days (total dose 2 g/kg). Response rate defined as a platelet count over 20,000 / μL 72 hours after initial treatment.

Results

Eighty one patients (52 male and 29 female) with mean age of 5 years and 3 months randomly divided in anti-D group (n=42) and IVIG group (n=39). Mean baseline (pretreatment) platelet counts were 15406 / μL and 15230/ μL in anti-D and IVIG group, respectively. The response rate in IVIG group (98%) was more significant than anti-D group (76%); (P = 0.017). After 7 days the platelet counts of all patients in IVIG group were more than 20,000/ μL while in anti-D group 12% had platelet counts below 20,000/ μL.

Conclusion

In acute childhood ITP, initial treatment with IVIG (2g/Kg in divided dose) increased platelet count more rapidly and more significant than intravenous anti-D (single dose of 75 μg/Kg) within the first 72 hours.

Key words

Intravenous immunoglobulin Intravenous anti-D immunoglobulin Children Acute immune thrombocytopenic purpura 

Copyright information

© Dr. K C Chaudhuri Foundation 2008

Authors and Affiliations

  • Elham Shahgholi
    • 1
    • 6
  • Parvaneh Vosough
    • 2
  • Kambiz Sotoudeh
    • 3
  • Khadijeh Arjomandi
    • 2
  • Shahla Ansari
    • 2
  • Soraya Salehi
    • 4
  • Mohammad Faranoush
    • 5
  • Mohammad Ali Ehsani
    • 1
  1. 1.Division of Hematology/Oncology, Department of PediatricsTehran University of Medical SciencesTehranIran
  2. 2.Division of Hematology/Oncology, Department of PediatricsIran University of Medical SciencesTehranIran
  3. 3.Research and Development CenterTehran University of Medical SciencesTehranIran
  4. 4.Department of PediatricsIran University of Medical SciencesTehranIran
  5. 5.Division of Hematology/Oncology, Department of PediatricsSemnan University of Medical SciencesSemnanIran
  6. 6.Department of Pediatric Hematology/OncologyBahrami Children’s HospitalTehranIran

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