Advertisement

Role of colostrum in gastrointestinal infections

Special Article

Abstract

Colostrum is breast milk produced after the birth of the newborn and lasts for 2–4 days. Colostrum is very important part of breast milk and lays down the immune system and confers growth factors and other protective factors for the young ones in mammals. This is the source of passive immunity transferred to the baby from the mother. The biological value of bovine colostrum in present day medical practice is documented in clinical trials and large databases containing case reports and anecdotal findings. The main actions include an antibacterial effect and modulation of immune response with the ability to neutralize lipopolysaccharides arising from gram negative bacterial pathogens. It has been found to be effective in infantile hemorrhagic diarrheas, other diarrheas and reduces the likelihood of disease progressing to hemolytic uremic syndrome. It has also been tested in H pylori infection and diarrhea in immunodeficiency. Side effects of clinical relevance are limited to possible intolerance due to lactose and sensitivity to milk proteins.

Key words

Colostrum Bovine colostrum GI infections 

References

  1. 1.
    Kaushik S, Trivedi SS, Jain A, Bhattcharjee J. Unusual changes in colostrum composition in lactating Indian women having medical complication during pregnancy-A pilot study. Indian J Clin Biochem 2002; 17: 68–73.CrossRefGoogle Scholar
  2. 2.
    Pakkanen R, Aalto J. Review paper-Growth factors and antimicrobial factors in bovine colostrum. Internat Diary J 1997; 7: 285–297.CrossRefGoogle Scholar
  3. 3.
    Boesman-Finkelstein M, Finkelstein R. Passive oral immunization in children. Lancet 1989; 2: 1336.PubMedCrossRefGoogle Scholar
  4. 4.
    Dicthtelmuller W, Lissner R. Antibodies from colostrum in oral immunotherapy. J Clin Biochem 1990; 28: 19–23.Google Scholar
  5. 5.
    Ogra SS, Ogra PL. Immunological aspects of human colostrum and milk. J Pediatr 1978; 92: 546–549.PubMedCrossRefGoogle Scholar
  6. 6.
    Antonius C M., van Hoojidonk, Kussendrager K D, Steijns J M. In vivo antimicrobial and antiviral activity of components in bovine mild and colostrum involved in non-specific defence. Br J Nutr 2000; 84 (S-1): S127–S134.Google Scholar
  7. 7.
    Davidson G, Whyte P, Daniels E et al. Passive immunization of children with bovine colostrum containing antibodies to human rotavirus. Lancet 1989; 2: 709–712.PubMedCrossRefGoogle Scholar
  8. 8.
    Bitzan M M, Gold B D, Phil Pott D J et al. Inhibition of H pylori and Helicobactor mustelae binding to lipid receptors by bovine colostrum. J Infect Dis 1998; 177: 955–961.PubMedGoogle Scholar
  9. 9.
    Bogstedt A K, Johansen K, Hatta H et al. Passive immunity against diarrhea. Acta Pediatr 1996; 85: 125–128.CrossRefGoogle Scholar
  10. 10.
    Lonnedal B, Iyer S. Lactoferrin molecular structure and biological function. Ann Review Nutr 1995; 15: 93–100.CrossRefGoogle Scholar
  11. 11.
    Bocc V, Von Breeman K, Corradeschi F et al. What is the role of cytokines in human colostrum? J Bio Regulat Homeo Agents 1991; 3: 121–124.Google Scholar
  12. 12.
    Lawton J W, Shortstride K F, Wong R Ng Mh. Interferon synthesis by human Colostral leucocytes. Arch Dis childhood 1979; 54: 127–130.Google Scholar
  13. 13.
    Bhora F, Dinkin B, Batzri S et al. Effect of growth factors on cell proliferation and epithelization in human skin. J Surg Res 1995; 59: 236–244.PubMedCrossRefGoogle Scholar
  14. 14.
    Francis G, Upton F, Ballard J et al. Insulin like growth factors 1 and 2 in bovine colostrums. J Biochem 1988; 251: 95–103.Google Scholar
  15. 15.
    Thapa B R. Health factors in colostrum. Indian J Pediatr 2005; 72: 579–581.PubMedCrossRefGoogle Scholar
  16. 16.
    Mero A, Kahkonen, Nykanen T et al. IGF-I, IgA and IgG responses to bovine colostrums supplementation during training. J Appl Physiol 2002; 93: 732–739.PubMedGoogle Scholar
  17. 17.
    Bocc V, Von Bremen K, Corradeschi F et al. What is the role of cytokines in human colostrum? J Bio Regulat Homeo Agents 1991; 3: 121–124.Google Scholar
  18. 18.
    Ahmed L, Nazrul Islam SK, Khan NI, Nahid SN. Vitamin C Content in Human Milk (Colostrum, Transitional and Mature) and serum of a sample of Bangladeshi Mothers. Mal J Nutr 2004; 10: 1–4.Google Scholar
  19. 19.
    Mitra A K, Mahatanabis D, Ashraf H et al. Hyperimmune cow colostrums reduces diarrhea due to rotavirus: a doubleblind, controlled clinical trial. Acta Pediatr 1995; 84: 996–1001.CrossRefGoogle Scholar
  20. 20.
    Sarkar S A, Casswall T H, Mahalanabis D’et al. Successful treatment of rotavirus diarrhea in children with immunoglobulin from immunized bovine colostrum. Pediatr Infect Dis J 1998, 17: 1149–1154.CrossRefGoogle Scholar
  21. 21.
    Brussow H. Hilpert H. Walther I. Sidoti J. Mietens C. Bachmann P. Bovine milk immunoglobulins for passive immunity to infantile rotavirus gastroenteritis. J Clin Microbiol 1987; 25: 982–986.PubMedGoogle Scholar
  22. 22.
    Tzipori S, Roberson D, Chapman C. Remission of diarrhea due to cryptosporidiosis in an immunodeficient child treated with hyperimmune bovine colostrums. BMJ 1986; 293: 1276–1277.PubMedCrossRefGoogle Scholar
  23. 23.
    Tzipori S, Robertson D, Cooper DA, While L. Chronic cryposporidial diarrhea and hyperimmue cow colostrums. Lancet 1987; 2: 344–345.PubMedCrossRefGoogle Scholar
  24. 24.
    Nord J, Ma P, Dijohn D, Tzipori S, Tacket Co. Treatment with bovine hyperimmune colostrums of cryptosporidial diarrhea in AIDS patients. AIDS 1990; 4: 581–584.PubMedCrossRefGoogle Scholar
  25. 25.
    Ungar BL, Ward DJ, Fayer R, Quinn CA. Cessation of Cryprosporidium-associated diarrhea in an acquired immunodeficiency syndrome patient after treatment with hyperimmune bovine colostrums. Gastroenterology 1990; 98: 486–489.PubMedGoogle Scholar
  26. 26.
    Rump JA, Amdt R, Arnold A, Bendick C, Dichtelmuller H. Franke M et al. Treatment of diarrhea in human immunodeficiency virus-infected patients with immunoglobulins from bovine colostrums. Clin Invest 1992; 70: 588–594.CrossRefGoogle Scholar
  27. 27.
    Lissner R, Schmidit H, Karch H. A standard immunoglobulin preparation produced from bovine colostra shows antibody reactivity and neutralization activity against shiga like toxin and EHEC hemolysin of Escherichia coli 0157: H7. J Infection 1996; 24: 378–383.CrossRefGoogle Scholar
  28. 28.
    Huppertz, HI, Rutkowski S, Busch DH et al. Bovine colostrum ameliorates diarrhea in infection with diarrheagenic Escherichia coli, shiga toxin producing E. coli and E. coli expressing intimin and hemolysin. J Pediatr Gastroenterol Nutr 1999; 29: 452–456.PubMedCrossRefGoogle Scholar
  29. 29.
    Bolke E, Jehle PM, Hausmann F et al. Preoperative oral application of immunoglobulin-enriched colostrum milk and mediator response during abdominal surgery. Shock 2002; 17: 9–12.PubMedCrossRefGoogle Scholar
  30. 30.
    Bolke E, Orth K, Jehle PM et al. Enteral application of immunoglobulin-enriched colostrum milk preparation for reducing endotoxin translocation and acute phase response in patients undergoing coronary bypass surgery-a randomized placebo controlled trial. Wien Klin Wochenschr 2002; 114: 923–928.PubMedGoogle Scholar

Copyright information

© Dr. K C Chaudhuri Foundation 2008

Authors and Affiliations

  1. 1.Division of Pediatric Gastroenterology, Department of GastroenterologyPost Graduate Institute Medical Education and Research (PGIMER)ChandigarhIndia

Personalised recommendations