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The Indian Journal of Pediatrics

, Volume 75, Issue 4, pp 331–333 | Cite as

Effects of Chichorium intybus on bilirubin

  • Hossain Nassirian
  • Saeedeh Tarvij Eslami
Original Article

Abstract

Objective

To evaluate the in vitro effects of chichorium intybus on bilirubin levels.

Methods

In this study the bilirubin levels in the serum of thirty neonates staying in the NICU and suffering from clinical jaundice was determined three times: first without any alterations, second after adding chichorium intybus extract and third after adding the same amount of distilled water. The results were compared using SPSS statistical software.

Results

Of the patients evaluated 76.7% were male and 23.3% were female. The average age was 7.35 days. The mean difference observed in unconjugated bilirubin levels in the specimens containing chichorium intybus extract was 3.84 ± 2.38 mg/dl and in the ones containing distilled water was 2.85 ± 2.00 mg/dl. The mean difference observed in conjugated bilirubin levels was 0.29 ± 0.32 mg/dl in specimens containing distilled water and 0.35 ± 0.26 in the ones containing chichorium intybus. In none of the cases the results were found to be significant.

Conclusion

In this study chichorium intybus was found to have no significant in vitro effect on the bilirubin level reported by the laboratory. The in vivo effects of this herbal medicine must be evaluated more closely.

Key words

Chichorium intybus Unconjugated hyperbilirubinemia Neonates 

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Refrences

  1. 1.
    Stoll B, Kliegman R. Jaundice and hyperbilirubinemia in the newborn. In Behemen R, Kliegman R, Jenson H. Nelson Textbook in Pediatrics, 17th ed. Philadelphia; Saunders, 2004; 592–596.Google Scholar
  2. 2.
    Martin RJ, Fanaroff AA, Walsh MC. Fanaroff and Martins neonatal-perinatal medicine: Diseases of the fetus and infant. In Wong RJ, Desander GH, Sibley E, Stevenson DK. Neonatal Jaundice and Liver Disease, 8th ed. Philadelphia; Mosby, 2006; 1443–1450.Google Scholar
  3. 3.
    Schleicher H. Phototherapy in pediatrics. Philadelphia; WB Saunders, 2002; 1–18.Google Scholar
  4. 4.
    Peti TP. Inhibitory effect of mast-cell mediated type allergic reactions. By cichorium intybus. Pharmacol Res 1999; 40: 61–65.CrossRefGoogle Scholar
  5. 5.
    Curhuz I, Ustun O, Yesilada, E et al. In vivo gasteroprotective effect of five Turkish folk remedies against ethanol-induced lesion. J Enteropharmacol 2002; 83: 241–244.Google Scholar
  6. 6.
    Huang W, Zhang J, Moore DD. A traditional herbal medicine enhances bilirubin clearance by activating the nuclear receptor CAR. J Clin Invest 2004; 113: 23–25.Google Scholar
  7. 7.
    Huseini HF, Alavian SM, Heshmat R, Heshmat R, Heydari MR, Abolmaali K. The efficacy of Liv-52 on liver cirrhotic patients: a randomized, double — blind, placebo-controlled first approach. Phytomedicine 2005; 12: 619–624.PubMedCrossRefGoogle Scholar
  8. 8.
    Kuo CY, Chang PC, Wei JS. The effect of decoction of Artemisia, Rheum, and Gardeniae in a piglet model of hyperbilirubinemia. Zhonghua Min Guo Ziao Er Ke Yi Xue Za Zhi 1996; 37: 253–256.Google Scholar
  9. 9.
    Ahmed B, Al-Howiriny TA, Siddiqui AB. Antihepatotoxic activity of seeds of cichorium intybus. J Ethnopharmacol 2003;87: 237–240.PubMedCrossRefGoogle Scholar

Copyright information

© Dr. K C Chaudhuri Foundation 2008

Authors and Affiliations

  1. 1.Department of PediatricsMashad Azad University, Faculty of Medical SciencesMashadIran

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