The Indian Journal of Pediatrics

, Volume 74, Issue 10, pp 915–916 | Cite as

Efficacy of permethrin cream and oral ivermectin in treatment of scabies

  • Sarfrazul Abedin
  • Manish Narang
  • Vijay Gandhi
  • Shiva Narang
Original Article

Abstract

Objective

To compare the efficacy of mass treatment of scabies with permethrin cream and oral ivermectin in a closed urban pediatric population.

Methods

A comparative trial of topical permethrin and oral ivermectin was conducted in a closed population of 84 children living in a urban hostel of Delhi.

Results

After mass treatment with 2 doses of oral ivermectin, one case was recorded in following 6 months, as compared to 22 cases in preceding 6 months when children were treated with a single application of 5% permethrin.

Conclusion

Mass treatment of scabies with ivermectin in an endemic population is more efficacious as compared to topical permethrin application in reducing the baseline prevalence, decreasing the chain of transmission and chances of reinfection.

Key words

Scabies Ivermectin Permethrin 

References

  1. 1.
    Taplin D, Meinking T. Infestations. In Schachner LA, Hansen RC, eds. Pediatric dermatology Vol 2. New York; Churchill Livingstone, 1988; 1465–1516.Google Scholar
  2. 2.
    Lawrence G, Leafasia J, Sheridan J, Hills S, Wate J, Wate C et al. Control of scabies, skin sores and haematuria in children in the Solomon Islands: another role for Ivermectin. Bull World Health Organ 2005; 83: 34–42.PubMedGoogle Scholar
  3. 3.
    Taplin D, Porcelain SL, Meinking TL, Athey RL, Chen JA, Castillero PM et al. Community control of scabies: a model based on use of Permethrin cream. Lancet 1991; 337: 1016–1018.PubMedCrossRefGoogle Scholar
  4. 4.
    Meinking TL, Taplin D, Hermida JL et al. The treatment of scabies with Ivermectin. N Engl J Med 1995; 333: 26–30.PubMedCrossRefGoogle Scholar
  5. 5.
    Aubin F, Humbert P. Ivermectin for crusted scabies. N Engl J Med 1995; 332: 612.PubMedCrossRefGoogle Scholar
  6. 6.
    Dourmishev A, Serfimova D, Dourmishev L. Efficacy and tolerance of oral Ivermectin in scabies. J Eur Acad Dermatol Venereol 1998; 11: 247–251.PubMedCrossRefGoogle Scholar
  7. 7.
    Pacque M, Munoz B, Greene BM, White AT, Dukuly Z, Taylor HR. Safety of and compliance with community based Ivermectin therapy. Lancet 1990; 335: 1377–1380.PubMedCrossRefGoogle Scholar
  8. 8.
    Gardon J, Gardon-Wendel N, Demanga N, Kamgno J, Chippaux JP, Boussinesq M. Serious reaction after mass treatment of onchocerciasis with Ivermectin in an area endemic for Loa Loa infection. Lancet 1997; 350: 18–22.PubMedCrossRefGoogle Scholar
  9. 9.
    Ribeiro Fde A, Taciro E, Guerra MR, Eckley CA. Oral Ivermectin for the treatment and prophylaxis of scabies in prison. J Dermatolog Treat 2005; 16: 138–141.PubMedCrossRefGoogle Scholar

Copyright information

© Dr. K C Chaudhuri Foundation 2007

Authors and Affiliations

  • Sarfrazul Abedin
    • 1
  • Manish Narang
    • 1
    • 2
  • Vijay Gandhi
    • 1
    • 3
  • Shiva Narang
    • 1
    • 4
  1. 1.Department of PediatricsRajiv Gandhi Cancer InstituteDelhiIndia
  2. 2.Department of PediatricsUniversity College of Medical Sciences and Guru Tegh Bahadur HospitalDelhiIndia
  3. 3.Department of DermatologyUniversity College of Medical Sciences and Guru Tegh Bahadur HospitalDelhiIndia
  4. 4.Department of MedicineUniversity College of Medical Sciences and Guru Tegh Bahadur HospitalDelhiIndia

Personalised recommendations