The Indian Journal of Pediatrics

, Volume 74, Issue 9, pp 827–830 | Cite as

Interaction between anemia and blood levels of iron, zinc, copper, cadmium and lead in children

  • Sebahat Turgut
  • Aziz Polat
  • Murat Inan
  • Günfer Turgut
  • Gülten Emmungil
  • Mevlüt Bican
  • Tugrul Yasin Karakus
  • Osman Genç
Original Article



Anemia is a widespread problem among infants and children in many parts of the world, and it is often associated with some trace elements (iron, zinc, copper) and heavy metals (cadmium and lead). Aim of this study was to investigate the relationship between anemia and these elements.


This research was performed on 256 children (mean age 6.8 ± 0.2) living in Denizli city center. We observed iron deficiency anemia (IDA) in 23 children, iron deficiency without anemia (ID) in 36 children and only anemia (ferritin level normal) (OA) in 18 children, and 179 children were found healthy and they were regarded as controls (C). Blood samples were taken from subjects and the concentrations of zinc, copper, iron, cadmium and lead in serum were measured with atomic absorption spectrophotometer.


The levels of copper, cadmium and lead in serum were significantly higher in children with IDA than those of controls (p<0.05, p<0.05, p<0.01, respectively). The other elements in the serum of ID were not different from controls.

Key words

Children Iron deficiency anemia Cadmium Copper Iron Zinc Lead 


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  1. 1.
    Hossny E, Mokhtar G, El-Awady M, Ali I, Morsy M, Dawood A. Environmental exposure of the pediatric age groups in Cairo City and its suburbs to cadmium pollution. Sci Total Environ 2001; 273(1–3): 135–146.PubMedCrossRefGoogle Scholar
  2. 2.
    Leroyer A, Hemon D, Nisse C, Bazarques J, Slumez JL, Haguenoer JM. Environmental exposure to lead in a population of adults living in northern France: lead burden levels and their determinens. Sci Total Environ 2001; 267(1–3): 87–99.PubMedCrossRefGoogle Scholar
  3. 3.
    Wrobel K, Wrobel K, Urbina EM. Determination of total aluminum, chromium, copper, iron, manganese and nickel and their fractions leached to the infusions of black tea, green tea, Hibiscus sabdariffa, and Ilex paraguariensis (mate) by ETA-AAS. Biol Trace Elem Res 2000; 78(1–3): 271–280.PubMedCrossRefGoogle Scholar
  4. 4.
    Morrison JN, Quarterman J. The relationship between iron status and lead absorption in rats. Biol Trace Elem Res 1987; 14: 1115–1126.Google Scholar
  5. 5.
    Schumann K. The toxicological estimation of the heavy metal content (Cd, Hg, Pb) in food for infants and small children. Z Ernahrungswiss 1990; 29(1): 54–73.PubMedCrossRefGoogle Scholar
  6. 6.
    Brown A, Halls JD, Taylor A. Atomic pectrometry updateclinical materials, foods and beverages. J Analytical Atomic Spectometry 1986; 1: 21–35.CrossRefGoogle Scholar
  7. 7.
    Lee GR. Iron deficiency and iron deficiency anemia. In: Lee GR, Foerster J, Lukens J, Paraskevas F, Greer JP, Rodgers GM, ed. Wintrobe’s clinical hematology (10th ed.), Baltimore: William and Wilkins, 1999: 979–999.Google Scholar
  8. 8.
    Andrews NC. Disorders of iron metabolism. New Eng J Med 1999; 341: 1986–1995.PubMedCrossRefGoogle Scholar
  9. 9.
    Ece A, Uyanik BS, Iscan A, Ertan P, Yigitoglu MR. Increased serum copper and decreased serum zinc levels in children with iron deficiency anemia. Biol Trace Elem Res 1997; 59(1–3): 31–39.PubMedGoogle Scholar
  10. 10.
    Newhouse IJ, Clement DB, Lai C. Effects of iron supplementation and discontinuation on serum copper, zinc, calcium, and magnesium levels in women. Med Sci Sports Exerc 1993; 25(5): 562–571.PubMedGoogle Scholar
  11. 11.
    Ayres RU. Toxic heavy metals: materials cycle optimisation. Proc Natl Acad Sci USA 1992; 89: 815–820.PubMedCrossRefGoogle Scholar
  12. 12.
    World Health Organization. Environmental Health Criteria 134: Cadmium, World Health Organization, Geneva, 1992.Google Scholar
  13. 13.
    Järup L, Berglund M, Elinder CG, Nordberg G, Vahter M. Health effects of cadmium exposure: A review of the literature and a risk estimate. Scand J Work Environ Health 1998; 24: 1–51.PubMedGoogle Scholar
  14. 14.
    Schümann K, Friebel P, Schmolke G, Elsenhans B. State of iron repletion and cadmium tissue accumulation as a function of growth in young rats after oral cadmium exposure. Arch Environ Contam Toxicol 1996; 31: 483–487.PubMedCrossRefGoogle Scholar
  15. 15.
    Park JD, Cherrington NJ, Klaassen CD. Intestinal absorption of cadmium is associated with divalent metal transporter 1 in rats. Toxicol Sci 2002; 68(2): 288–294.PubMedCrossRefGoogle Scholar
  16. 16.
    Willows ND, Gray-Donald K. Blood lead concentrations and iron deficiency in Canadian aboriginal infants. Sci Total Environ 2002; 289(1–3): 255–260.PubMedCrossRefGoogle Scholar
  17. 17.
    Kaul B. Lead exposure and iron deficiency among Jammu and New Delhi children. Indian J Pediatr 1999; 66: 27–35.PubMedCrossRefGoogle Scholar
  18. 18.
    Wright RO, Tsaih SW, Schwartz J, Wright RJ, Hu H. Association between iron deficiency and blood lead level in a longitudinal analysis of children followed in an urban primary care clinic. J Pediatr 2003; 142: 9–14.PubMedCrossRefGoogle Scholar
  19. 19.
    Kaufmann RB, Clouse TL, Olson DR, Matte TD. Elevated blood lead levels and blood lead screening among US children aged one to five years: 1988–1994. Pediatrics 2000; 106(6): E79.PubMedCrossRefGoogle Scholar
  20. 20.
    Nagano T, Toyoda T, Tanabe H, Nagato T, Tsuchida T, Kitamura A, Kasai G. Clinical features of hematological disorders caused by copper deficiency during long-term enteral nutrition. Intern Med 2005; 44(6): 554–559.PubMedCrossRefGoogle Scholar

Copyright information

© Dr. K C Chaudhuri Foundation 2007

Authors and Affiliations

  • Sebahat Turgut
    • 1
  • Aziz Polat
    • 2
  • Murat Inan
    • 2
  • Günfer Turgut
    • 1
  • Gülten Emmungil
    • 1
  • Mevlüt Bican
    • 2
  • Tugrul Yasin Karakus
    • 2
  • Osman Genç
    • 1
  1. 1.Department of PhysiologyPamukkale University Faculty of MedicineDenizliTurkey
  2. 2.Department of PediatricsPamukkale University Faculty of MedicineDenizliTurkey

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