The Indian Journal of Pediatrics

, Volume 74, Issue 8, pp 735–738 | Cite as

Blood transfusion rate in congolese patients with sickle cell anemia

  • L. M. TshiloloEmail author
  • R. K. Mukendi
  • S. O. Wembonyama
Original Article



The main objective of this study was to evaluate the rate of blood transfusion in African Sickle Cell Patients and the risks related to the use of total blood.


186 sickle cell patients (95 males and 91 females) aged 0–21 years were regularly followed over a 3 years period in Katanga province, DR Congo. Indications for blood transfusion were mainly based on clinical criteria and Hb level (less than 5g% ml or a drop of 2g% under the steady state value). All the subjects, who were transfused, wer screened for hepatitis B surface antigen (HBs Ag) and Human Immune deficit Virus (HIV).


Of 186 patients, 150 (80.6%) were transfused, and the average blood transfusion requirement was 0.4 units per patient-year. According to the age of first transfusion, 75.3% (113/150) of them were transfused before the 6th year of life; but the frequency of transfusions seemed to decline in children aged more than 13 years. The risk of HIV infection from blood transfusion was estimated at 1 per 37.1 units or 26 per 1000 blood units. The hepatitis B surface antigen was detected in 15 cases (10%) and HIV serology was positive in 17 patients (11.3%).


Because of the complications related to blood transfusions in Africa, efforts are needed in order to reduce the frequency of transfusions, by preventive measures (early diagnosis, malarial and penicillin-prophylaxis) and to use more rational indications.

Key words

Congolese Sickle cell anemia Blood transfusion HIV risk 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Brewster DR. Blood transfusion for severe anameia in African children. Lancet 1992; 340(10): 917.PubMedCrossRefGoogle Scholar
  2. 2.
    Lanckriet C, Koula RM, Bureau JJ, Capdevielle H et al. Les anemies severes ayant necessite use transfusion dans le service de Pediatrie de Bangui (Centrafrique). Ann Pediatr (Paris) 1995; 42(1): 60–64.Google Scholar
  3. 3.
    Greenberg AE, Nguyen-Dinh P, Mann JM et al. The association between malaria, blood transfusions, and HIV seropositivity in a pediatric population in Kinshasa. JAMA 1988; 259: 545–549.PubMedCrossRefGoogle Scholar
  4. 4.
    Girot R. Les modalites de la transfusion sanguine dans la drepanocytose et dans la thalassemia. Transfus Clin Biol 1994; 1: 19–21.PubMedCrossRefGoogle Scholar
  5. 5.
    Montalembert M, Guilloud-Bataille M, Feingold C et al. Epidemiological and clinical study of sickle cell disease in France, French Guyana and Algeria. Eur J Haematol 1993; 51: 136–140.PubMedCrossRefGoogle Scholar
  6. 6.
    Diagne N, Diagne-Gueye H, Signate-Sy B et al. Prise en charge de la drepanocytose chez l’enfant en Afrique: experience de la cohorte de l’Hospital d’Enfants Albert Royer de Dakar. Med Trop 2003; 63: 513–520.Google Scholar
  7. 7.
    Wembonyama O, Ngwanza N, Tshilolo M et al. L’appreciation de l’urgence transfusioelle dans un service de pediatrie (a’propos de 250 observations. Bull Soc Pathol Exot 1991; 84: 205.Google Scholar
  8. 8.
    Nduka N, Owhochuku SM and Odike P. Current observations on Sickle Cell genotype in Nigeria. East Afr Med J 1993; 70(10): 646–649.PubMedGoogle Scholar
  9. 9.
    Tshilolo L, Mukendi R, et Girot. La drepanocytose dans le Sud du Zaire. Etude de deux series de 251 et 340 malades suivis entre 1988 et 1992. Arch Pediatr 1996; 3: 104–111.PubMedCrossRefGoogle Scholar
  10. 10.
    Tshilolo. La drepanocytose en Republique Democratique du Congo: apercu sur la sisituation actuelle et perspectives d’avenir. Congo Medical 2003; 3(12): 1044–1052.Google Scholar
  11. 11.
    Luzzato L. Sickle cell anaemia in tropical african clinics. Haematology 1981; 10(3): 757–784.Google Scholar
  12. 12.
    Galacteros F. Sickle cell disease: a short guide to management. In Disorders of iron homeostasis, erythrocytes, erythropoiesis. Genoa: Forum service ed, 2006: 276–309.Google Scholar
  13. 13.
    Syed SM, Sears DA, Werch JB, Udden MM, Milan JD Case reports: Delayed Hemolytic Transfusion Reaction in Sickle Cell Disease. Am J Med Sci 1996; 312(4): 175–181.PubMedCrossRefGoogle Scholar
  14. 14.
    Adeodu OO, Adekile AD. Clinical and laboratory features associated with persistent gross splenomegaly in Nigerian children with sickle cell anaemia. Act Paediatr Scand 1990; 79: 686–690.Google Scholar
  15. 15.
    Buchanan GR, McKie V, Jackson EA et al. Splenic phagocytic function in children with sickle cell anaemia receiving long-term hypertransfusion therapy. J Pediatr 1989; 115: 568–572.PubMedCrossRefGoogle Scholar
  16. 16.
    Nzingoula S. L’Hospital et la drepanocytose. In Galacteros F, Drepanocytose et sante publique. Colloque. Paris: Inserm ed, 1991; 161–171.Google Scholar
  17. 17.
    Laleman G, Magazani K, Perriens J et al. Prevention of blood-borne HIV transmission using a decentralised approach in Shaba, Zaire. AIDS 1992; 6: 1353–1358.PubMedCrossRefGoogle Scholar
  18. 18.
    Aken-Ova YA, Olasode BJ, Ogunbiy JO et al. Hepatobiliary changes in Nigerians with sickle cell anaemia. Ann Trop Med Parasitol 1993; 87(6): 603–606.Google Scholar

Copyright information

© Dr. K C Chaudhuri Foundation 2007

Authors and Affiliations

  • L. M. Tshilolo
    • 1
    Email author
  • R. K. Mukendi
    • 2
  • S. O. Wembonyama
    • 3
  1. 1.Centre de Formation et d’Appui SanitaireCentre Hospitalier MonkoleKinshasa XIRep. Dem du Congo
  2. 2.Clinique Universitaire St LucBrusselsBelgium
  3. 3.Hôpital Général Sendwe, Faculté de MédecineUniversité de Lubumbashi, Service Medical GecaminesKatangaRD Congo

Personalised recommendations