The Indian Journal of Pediatrics

, Volume 74, Issue 5, pp 505–506 | Cite as

Bleomycin induced hyperpigmentation with yolk sac tumor

  • Nilgun Yaris
  • Murat ÇakirEmail author
  • Mukaddes Kalyoncu
  • Okten Aysenur
Clinical Brief


Hyperpigmentation is one of the cutaneous side effects of chemotherapautic agents, but it is usually accepted as a cosmetic problem. We report a child with yolk sac tumor who developed localized pigmentation after the first course of chemotherapy regimen that included cisplatin, etoposide and bleomycin. The hyperpigmentation was diffuse scattered, flagellate like and linear streaking which was thought to be mainly related to the skin toxicity of bleomycin.

Key words

Bleomycin-induced Flagellate like Hyperpigmentation 


  1. 1.
    Haskell CM. Antineoplastic agents. In Haskell CM, eds. Cancer Treatment. 4th ed. Sounders WB Co/Med, 1995; 166.Google Scholar
  2. 2.
    Susser WS, Whitaker-Worrth DL, Grant-Kels JM. Mucocutaneous reactions to chemotherapy. J Am Acad Dermatol 1999; 40: 367–398.PubMedCrossRefGoogle Scholar
  3. 3.
    Mutafoglu-Uysal K, Sarialioglu F, Olgun N. Bleomycininduced hyperpigmentation and hypersensitivity reactions to etoposide and vinblastine in a child with endodermal sinus tumor. Turk J Pediatr 2001; 43: 172–174.PubMedGoogle Scholar
  4. 4.
    Dubra P, Ilchyshyn A, Das R. Bleomycin-induced flagellate erythema. Clin Exp Dermatol 1991; 16: 216–217.CrossRefGoogle Scholar
  5. 5.
    Schuler G, Aubock J, Huber H. Bleomycin-induced linear hyperpigmentation. Hautarzt 1984; 35: 383–386.PubMedGoogle Scholar
  6. 6.
    Vonhilsheimer GE, Norton SA. Delayed bleomycin-induced hyperpigmentation and pressure on the skin. J Am Acad Dermatol 2002; 46: 642–643.PubMedCrossRefGoogle Scholar
  7. 7.
    Lindae ML, Hu CH, Nickoloff BJ. Pruritic erythematous linear plaques on the neck and back. “Flagellate” erythema secondary to bleomycin therapy. Arch Dermatol 1987; 123: 395–398.PubMedCrossRefGoogle Scholar

Copyright information

© Dr. K C Chaudhuri Foundation 2007

Authors and Affiliations

  • Nilgun Yaris
    • 1
  • Murat Çakir
    • 2
    Email author
  • Mukaddes Kalyoncu
    • 2
  • Okten Aysenur
    • 2
  1. 1.Department of Pediatric OncologyTechnical University, Faculty of MedicineTrabzonTurkey
  2. 2.Department of Pediatrics KaradenizTechnical University, Faculty of MedicineTrabzon, İzmirTurkiye

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