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Feasibility of a deep hyperthermia and radiotherapy programme for advanced tumors: first Spanish experience

  • M. LloretEmail author
  • L. García-Cabrera
  • A. Hernandez
  • N. Santana
  • L. López-Molina
  • P. C. Lara
Brief Research Article

Abstract

Background

Hyperthermia (HT) is used to increase the temperature of the tumor-sensitizing cells to the effects of radiation/chemotherapy. We aimed to assess the feasibility, tolerability and safety of hyperthermia treatment in a Radiation Oncology Department.

Methods

Between June 2015 and June 2017, 106 patients and a total of 159 tumor lesions were included in a prospective study (EudraCT 2018-001089-40) of HT concomitant with radiotherapy (RT). Systemic treatment was accepted. HT was given twice a week, 60 min per session, during RT treatment by a regional capacitive device (HY-DEEP 600WM system) at 13.56 MHz radiofrequency.

Results

Most lesions (138 cases, 86.8%) received all HT sessions planned. Thirteen lesions (12 patients) withdrew treatment due to grade ≥3 QMHT toxicity. All these 12 patients completed the prescribed radiotherapy and/or systemic treatment.

Conclusions

Regional hyperthermia is a feasible and safe technique to be used in combination with radiotherapy and systemic treatment.

Keywords

Hyperthermia Radiotherapy Advanced tumors 

Notes

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval (Research involving human participants and/or animals)

All human studies have been approved by the appropriate ethics committee and have, therefore, been performed in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki and its later amendments.

Informed consent

All the persons gave their informed consent prior to their inclusion in the study and details that might disclose the identity of the subjects under study were omitted.

References

  1. 1.
    Dewhirst MW, Vujaskovic Z, Jones E, et al. Re-setting the biologic rationale for thermal therapy. Int J Hyperth. 2005;21(8):779–90.  https://doi.org/10.1080/02656730500271668.CrossRefGoogle Scholar
  2. 2.
    Peeken JC, Vaupel P, Combs SE. Integrating hyperthermia into modern radiation oncology: what evidence is necessary? Front Oncol. 2017;7:132.  https://doi.org/10.3389/fonc.2017.00132.CrossRefGoogle Scholar
  3. 3.
    Datta NR, Puric E, Klingbiel D, et al. Hyperthermia and Radiation therapy in locoregional recurrent breast cancers: a systematic review and meta-analysis. Int J Radiat Oncol Biol Phys. 2016;94(5):1073–87.  https://doi.org/10.1016/j.ijrobp.2015.12.361.CrossRefGoogle Scholar
  4. 4.
    National Comprehensive Cancer Network (NCCN) Guidelines. Version 3.2018—October 2018. Breast Cancer. http://www.nccn.org/professionals/physician_gls/pdf/breast.pdf. Accessed 28 January 2019.
  5. 5.
    Benot S. Efectividad y seguridad de la hipertermia en combinación con radioterapia y/o quimioterapia en el tratamiento del cáncer de mama, cérvix y recto. Agencia Evaluadora de Tecnologías Sanitarias de Andalucia (AETSA). 2004.  https://doi.org/10.13140/rg.2.2.21161.90727.
  6. 6.
    Sahinbas H, Rosch M, Demiray M. Temperature measurements in a capacitive system of deep loco-regional hyperthermia. Electromagn Biol Med. 2017;36(3):248–58.  https://doi.org/10.1080/15368378.2017.1307221.CrossRefGoogle Scholar
  7. 7.
    Hamazoe R, Maeta M, Murakami A, et al. Heating efficiency of radiofrequency capacitive hyperthermia for treatment of deep- seated tumors in the peritoneal cavity. J Surg Oncol. 1991;48:176–9 PMID: 1943113.CrossRefGoogle Scholar
  8. 8.
    Lagendijk JJW, van Rhoon GC, Hornsleth SN, et al. ESHO quality assurance guidelines for regional hyperthermia. Int J Hyperth. 1998;14(2):125–33 PMID: 9589319.CrossRefGoogle Scholar
  9. 9.
    Wust P, Gellermann J, Harder C, et al. Rationale for using invasive thermometry for regional hyperthermia of pelvic tumors. Int J Radiat Oncol Biol Phys. 1998;41(5):1129–37.  https://doi.org/10.1016/S0360-3016(98)00165.CrossRefGoogle Scholar
  10. 10.
    Crezee H, van Leeuwen CM, Oei AL, et al. Thermoradiotherapy planning: integration in routine clinical practice. Int J Hyperth. 2015;32(1):41–9.  https://doi.org/10.3109/02656736.2015.1110757.CrossRefGoogle Scholar
  11. 11.
    Ohguri T, Imada H, Yahara K, et al. Radiotherapy with 8-MHz radiofrequency-capacitive regional hyperthermia for stage III non-small-cell lung cancer: the radiofrequency-output power correlates with the intraesophageal temperature and clinical outcomes. Int J Radiat Oncol Biol Phys. 2009;73(1):128–35.  https://doi.org/10.1016/j.ijrobp.2008.03.059.CrossRefGoogle Scholar
  12. 12.
    Bruggmoser G, Bauchowitz S, Canters R, et al. Quality assurance for clinical studies in regional deep hyperthermia. Strahlenther Onkol. 2011;187(10):605–10.  https://doi.org/10.1007/s00066-011-1145-x.CrossRefGoogle Scholar
  13. 13.
    Bruggmoser G, Bauchowitz S, Canters R, et al. Guideline for the clinical application, documentation and analysis of clinical studies for regional deep hyperthermia. Quality management in regional deep hyperthermia. Strahlenther Onkol. 2012;188(Suppl 2):198.  https://doi.org/10.1007/s00066-012-0176-2.CrossRefGoogle Scholar
  14. 14.
    Grupo Español de Hipertermia https://www.hipertermiaoncologica.es/documentos. Accessed 28 January 2019.

Copyright information

© Federación de Sociedades Españolas de Oncología (FESEO) 2019

Authors and Affiliations

  1. 1.Department of Radiation OncologyDr. Negrin HospitalLas Palmas de Gran CanariaSpain
  2. 2.Universidad de Las Palmas de Gran CanariaLas PalmasSpain
  3. 3.Instituto Canario de Investigación del CáncerLas Palmas de Gran CanariaSpain
  4. 4.Universidad Fernando Pessoa CanariasLas PalmasSpain
  5. 5.Hospital Universitario San RoqueLas PalmasSpain

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