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Clinical and Translational Oncology

, Volume 21, Issue 12, pp 1634–1643 | Cite as

Assessment of the effect of the Aquamantys® system on local recurrence after hepatectomy for hepatocellular carcinoma through propensity score matching

  • M. H. Sui
  • H. G. Wang
  • M. Y. Chen
  • T. Wan
  • B. Y. Hu
  • Y. W. Pan
  • H. Li
  • H. Y. Cai
  • C. Cui
  • S. C. LuEmail author
Research Article
  • 65 Downloads

Abstract

Objective

To assess the effect of the intraoperative application of the Aquamantys® system to treat the hepatic resection margin on local and overall recurrence of HCC.

Methods

We retrospectively analyzed 101 patients admitted from November 2016 to June 2018 who underwent hepatectomy using the Aquamantys® as hemostatic device, who were matched with 101 patients (control group) using conventional hemostatic devices through PSM. Univariate and multivariate analyses of recurrence-free survival (RFS) and local recurrence-free survival (LRFS) were performed using the Cox proportional hazard model.

Results

There were no significant differences in baseline data and surgical procedures between the two groups. The Aquamantys® group showed less blood loss (P = 0.005) and a lower blood transfusion rate (P = 0.036), while the incidences of postoperative complications of the two groups showed no difference (P = 0.266). OS rates of the Aquamantys® group and the control group were 82.6% and 84.2%, respectively (P = 0. 446), and RFS rates were 65.5% and 58.2%, respectively (P = 0.153), with no significant differences. The Aquamantys® group and the control group had two cases and 11 cases of local recurrence, respectively, with LRFS rates of 98% and 87.9%, respectively, in the follow-up period, corresponding to a significant difference (P = 0.011). Multivariate analysis showed that microvascular invasion (MVI), tumor diameter > 5 cm, and the control group were independent risk factors for LRFS.

Conclusion

Our results indicate that application of the Aquamantys® system in hepatectomy can reduce local recurrence, but it can neither reduce overall recurrence nor improve OS.

Keywords

Hepatocellular carcinoma Hepatectomy Margin Recurrence Aquamantys 

Notes

Acknowledgements

This study was supported by funds from National Key R & D Program of China; National Natural Science Foundation of China.

Compliance with ethical standards

Conflict of interest

All the authors declare that there is no conflict of interest in this work.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. This study was approved by the hospital ethics committee and conducted in accordance with medical ethics regulations.

Informed consent

Informed consent was obtained from all individual participants included in the study.

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Copyright information

© Federación de Sociedades Españolas de Oncología (FESEO) 2019

Authors and Affiliations

  1. 1.Medical School of Chinese PLABeijingChina
  2. 2.Department of Hepatobiliary SurgeryChinese PLA General HospitalBeijingChina
  3. 3.NanKai UniversityTianjinChina

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