Incidence and survival of central nervous system tumors in childhood and adolescence in Girona (Spain) 1990–2013: national and international comparisons
Pediatric central nervous system tumors are one of the most frequent types of neoplasms in children but epidemiological data on these tumors have been sparsely reported in the medical literature.
Materials and methods
We analyze the epidemiology of this type of tumors performing a retrospective population-based study in pediatrics and adolescent age in the population of Girona and compare them with series from Spain, Europe and worldwide. Cases were registered using the International Classification of Disease for Oncology, third edition and grouping according the International Classification of Childhood Cancer, third edition (ICCC-3).
For all the histologies and the whole population between 0 and 19 years old, ASRw was 41.8 cases per million person-years. In children population, meaning under 14 years old, we found 104 cases with ASRw of 45.6. Males were the most affected by CNS tumors with a 1.2 sex ratio between 0 and 14 years old, and 1.1 between 0 and 19 years old. The analysis of trends in incidence did not find any statistically significant increase or decrease. Five-year observed survival was 68%, both for patients under 19 and 14 years of age.
The incidence in our area was among the highest in Spain and worldwide, while survival was comparable to others reported.
KeywordsChildhood cancer CNS tumors Incidence Survival Cancer registries Population-based study Epidemiology
List of abbreviations
Automated Childhood Cancer Information System
Age-standardized rate (using European Standard Population)
Age-standardized rate (using World Standard Population)
Central nervous system
Death certificate only
Estimated annual percentage of change
Girona Cancer Registry
International Agency for Research on Cancer
International Classification of Disease for Oncology, third edition
International Classification of Childhood Cancer, third edition
International Incidence of Childhood Cancer
Not otherwise specified (unspecified tumors)
We thank Katie Linder for the review of English grammar.
Compliance with ethical standards
Conflict of interest
The authors declare that they have no conflict of interest.
This study was in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.
The Epidemiology Unit and Girona Cancer Registry (GCR) is a statistical unit part of the Pla estadístic de Catalunya approved to produce official estiamtes of cancer incidence and mortality. The GCR studies are except of inform consent as they involve large datasets, are retrospective and observational, characteristics that make consent impractical to collect. Nonetheless, security measures are taken accordingly in order to protect patient confidentiality.
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