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Clinical and Translational Oncology

, Volume 21, Issue 3, pp 373–379 | Cite as

Retroperitoneal fibrosis secondary to non-urology carcinomas: a clinical and outcome analysis of 97 cases

  • T. Chen
  • L. Tian
  • D. Fan
  • F. Wu
  • J. LuEmail author
  • S. Ding
Research Article
  • 42 Downloads

Abstract

Purpose

Accumulated evidences have reminded us that since the prognosis of retroperitoneal fibrosis (RPF) secondary to non-urology carcinoma is poor it is essential to distinguish this condition from others. The objective of this study is to investigate the clinical features and outcomes of this infrequent but life-threatening disease.

Methods

A total of 97 patients diagnosed with RPF secondary to non-urology carcinoma were enrolled in this retrospective study. The baseline information, history of carcinoma, clinical presentation, laboratory results, diagnosis, treatment and prognosis of the patients were collected and analyzed.

Results

The mean age was 62.32 ± 11.22 years (range 31–85 years). It took 16.72 ± 7.11 days (range 3–34 days) for the patients with originally unexplained hydronephrosis to get a definite diagnosis of RPF secondary to non-urology carcinoma. Imaging-confirmed RPF [confirmed by computed tomography (CT) or magnetic resonance imaging (MRI)] was found in 91 patients. Fifty-seven patients were diagnosed with histological-confirmed malignant RPF. Sixty-six patients received surgical interventions. Cystoscopy and double J tube were performed in 68 cases (102 sides, 172 times) and was failed in 93 times (54.07%). Pyelostomy was performed in 72 patients (92 sides) without a single failure. Furthermore, eighty patients received chemotherapy and/or radiotherapy. The 6-month survival since RPF secondary to non-urology carcinoma was confirmed was 30%.

Conclusions

All patients with newly diagnosed unexplained hydronephrosis should undergo an age-appropriate carcinoma screening. The prognosis of RPF secondary to non-urology carcinoma was dismal. When dealing with hydronephrosis affecting renal function, pyelostomy instead of double J tube catheterization should be performed ahead of time.

Keywords

Carcinoma Hydronephrosis Prognosis Retroperitoneal fibrosis 

Notes

Acknowledgements

We appreciate a grant from Shandong Province Key Research and Development Program (No.2016GGB14312) and a grant from Shandong Province Medicine Heath Science Technology Development Program (No. 2016WS0425) for supporting our study. Besides, we thank Zhao Liu from Department of Urology, Qilu Hospital of Shandong University for proof reading of our manuscript.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

This study was conducted in compliance with ethical principles based on the 1964 Declaration of Helsinki and with the approval of the ethics committee of Shandong Provincial Hospital Shandong University.

Informed consent

Informed consent was obtained from all individual participants included in this study.

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Copyright information

© Federación de Sociedades Españolas de Oncología (FESEO) 2018

Authors and Affiliations

  1. 1.Department of Pediatric SurgeryShanghai Children’s Hospital, Shanghai Jiao Tong UniversityShanghaiPeople’s Republic of China
  2. 2.Guilin Medical UniversityGuilinPeople’s Republic of China
  3. 3.Department of UrologyShandong Provincial Qianfoshan HospitalJinanPeople’s Republic of China
  4. 4.Department of UrologyShandong Provincial Hospital Affiliated to Shandong UniversityJinanPeople’s Republic of China

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