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Clinical and Translational Oncology

, Volume 21, Issue 3, pp 298–303 | Cite as

Prognostic implication of EGFR mutation status and subtype in resected lung adenocarcinoma patients irrespective of therapy

  • R. Li
  • Q. Li
  • S. Lin
  • W. Li
  • L. Yu
  • L. Wang
  • X. Dong
  • L. Yu
  • S. Li
  • W. Liu
  • B. LiEmail author
Research Article
  • 71 Downloads

Abstract

Objective

This study aimed to investigate the pure prognostic role of epidermal growth factor receptor (EGFR) mutation status and subtype in lung adenocarcinoma patients irrespective of therapy.

Materials and methods

We retrospectively enrolled 119 cases of completely resected pathological stage I lung adenocarcinoma patients who received no postoperative chemotherapy or tyrosine kinase inhibitors. EGFR gene mutations from 18 to 21 exons were tested for all the patients. Disease-free survival (DFS) and overall survival (OS) were compared between patients with different EGFR mutation status and subtype using Kaplan–Meier methods.

Results

EGFR mutations were detected in 54 (45.4%) patients including two common mutation subtypes: 32 in-frame deletion within exon 19 (19del) and 19 point mutation within exon 21 (L858R). The frequency of EGFR mutations was much greater for patients of non-smokers versus current or ever smokers (58.1 versus 24.4%, P = 0.000), and a little greater for females versus males (53.8 versus 35.2%, P = 0.042). The median follow-up duration was 43.5 months, and there were no differences on DFS (P = 0.461) and OS (P = 0.989) between patients with EGFR mutations and those without in univariate analysis. The patients harboring 19del mutation had a better DFS (P = 0.028) and OS (P = 0.001) than the patients harboring L858R mutation with significant statistical difference.

Conclusions

This study suggests that there is no difference on survival between patients with EGFR mutations and those without, but the patients harboring EGFR 19del mutation have survival advantage compared to those harboring EGFR L858R mutation.

Keywords

Lung adenocarcinoma EGFR mutation Prognosis 19del mutation L858R mutation 

Notes

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Research involving human participants and/or animals and informed consent

The research is a retrospective study. All the lung cancer patients in this study received radical resection in two hospitals between April 2009 and June 2014. We just investigate the disease-free survival and overall survival between patients with different EGFR mutation status and subtype. So the above statement is not necessary for this research.

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Copyright information

© Federación de Sociedades Españolas de Oncología (FESEO) 2018

Authors and Affiliations

  1. 1.Department of Radiation OncologyShandong Cancer Hospital and Institute Affiliated to Shandong UniversityJinanChina
  2. 2.Department of Oncology IIYantai Affiliated Hospital of Binzhou Medical UniversityYantaiChina
  3. 3.Department of Radiation OncologyTianjin Medical University Cancer Institute and HospitalTianjinChina

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