Radiotherapy volume delineation using 18F-FDG-PET/CT modifies gross node volume in patients with oesophageal cancer
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Evidence supporting the use of 18F-FDG-PET/CT in the segmentation process of oesophageal cancer for radiotherapy planning is limited. Our aim was to compare the volumes and tumour lengths defined by fused PET/CT vs. CT simulation.
Materials and methods
Twenty-nine patients were analyzed. All patients underwent a single PET/CT simulation scan. Two separate GTVs were defined: one based on CT data alone and another based on fused PET/CT data. Volume sizes for both data sets were compared and the spatial overlap was assessed by the Dice similarity coefficient (DSC).
The gross tumour volume (GTVtumour) and maximum tumour diameter were greater by PET/CT, and length of primary tumour was greater by CT, but differences were not statistically significant. However, the gross node volume (GTVnode) was significantly greater by PET/CT. The DSC analysis showed excellent agreement for GTVtumour, 0.72, but was very low for GTVnode, 0.25.
Our study shows that the volume definition by PET/CT and CT data differs. CT simulation, without taking into account PET/CT information, might leave cancer-involved nodes out of the radiotherapy-delineated volumes.
Keywords18F-FDG-PET/CT Delineation Oesophageal Radiotherapy
Compliance with ethical standards
Conflict of interest
No conflict of interest of any author.
All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutitional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.
As this study is retrospective study, formal content is not required.
- 19.Schreurs LM, Busz DM, Paardekooper GM, et al. Impact of 18-fluorodeoxyglucose positron emission tomography on computed tomography defined target volumes in radiation treatment planning of esophageal cancer: reduction in geographic misses with equal inter-observer variability: PET/CT improves esophageal target definition. Dis Esophagus. 2010;23:493–501.CrossRefGoogle Scholar
- 20.Ward G, Ramasamy S, Sykes JR, et al. Superiority of deformable image co-registration in the integration of diagnostic positron emission tomography-computed tomography to the radiotherapy treatment planning pathway for oesophageal carcinoma. Clin Oncol (R Coll Radiol). 2016;28:655–62.CrossRefGoogle Scholar