Incidence of sleep problems and their mediating role on depression and anxious preoccupation in patients with resected, non-advanced cancer: data from NEOcoping study

  • C. Calderon
  • A. Carmona-Bayonas
  • R. Hernandez
  • B. Castelo
  • S. Varma
  • O. Donnay
  • D. Gomez
  • P. Jimenez-FonsecaEmail author
Brief Research Article



Our study analyzes the incidence of sleep problems and their mediating role on depression and anxious preoccupation in patients with resected, non-advanced cancer.


A multi-institutional, prospective, observational study was conducted with 750 participants of 14 hospitals in Spain. Participants’ socio-demographic and clinical characteristics were collected using a standardized self-report form and using EORTC QoL-QLQ-C30, BSI, Mini-MAC questionnaires.


In women, sleep problems, depression and anxious preoccupation were observed in 65, 41 and 21%, respectively. In men, sleep problems, depression and anxious preoccupation were reported in 51, 29 and 61%, respectively. More sleep problems, depression and anxious preoccupation were found among women than males. Depression was a significant predictor of anxious preoccupation. In males, sleep problems partially mediated this association. This was not confirmed in women.


Our findings point toward the importance of developing interventions that decrease depression and sleep problems in cancer.


Adjuvant chemotherapy BSI Coping EORTC-QoL-QLQ-C30 Mini-MAC Quality of life 



The authors would like to thank the investigators of the NEOcoping study, the Supportive Care Working Group of the Spanish Society of Medical Oncology (SEOM), Natalia Cateriano, Miguel Vaquero and IRICOM S.A. for the support of the website registry, and Priscilla Chase Duran for editing the manuscript.

Sources of funding

This work was funded by the Spanish Society of Medical Oncology (SEOM) in 2015. The sponsor of this research has not participated in data collection, analysis, or interpretation, in writing the report, or in the decision to submit the article for publication.

Compliance with ethical standards

Conflict of interest

The authors have declared no conflict of interest.

Ethical approval (research involving human participants and/or animals)

The study has been performed in accordance with the ethical standards of the Declaration of Helsinki and its later amendments. This study is an observational, non-interventionist trial.

Informed consent

Signed informed consent was obtained from all patients.


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Copyright information

© Federación de Sociedades Españolas de Oncología (FESEO) 2019

Authors and Affiliations

  1. 1.Department of Clinical Psychology and Psychobiology, Faculty of PsychologyUniversity of BarcelonaBarcelonaSpain
  2. 2.Department of Hematology and Medical OncologyHospital Universitario Morales Meseguer, UMU, IMIBMurciaSpain
  3. 3.Department of Medical OncologyHospital Universitario de CanariasTenerifeSpain
  4. 4.Department of Medical OncologyHospital Universitario La PazMadridSpain
  5. 5.Department of Medical OncologyHospital Universitario La PrincesaMadridSpain
  6. 6.Department of Medical OncologyHospital Universitario Central of AsturiasOviedoSpain

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