Cancer survival in adult patients in Spain. Results from nine population-based cancer registries
- 613 Downloads
With the aim of providing cancer control indicators, this work presents cancer survival in adult (≥15 years) patients in Spain diagnosed during the period 2000–2007 from Spanish cancer registries participating in the EUROCARE project.
Cancer cases from nine Spanish population-based cancer registries were included and analysed as a whole. All primary malignant neoplasms diagnosed in adult patients were eligible for the analysis. Cancer patients were followed until 31 December 2008. For each type of cancer, 1-, 3- and 5-year observed and relative survival were estimated by sex, age and years from diagnosis. Furthermore, age-standardized 5-year relative survival for the period 2000–2007 has been compared with that of the period 1995–1999.
Skin melanoma (84.6 95% CI 83.0–86.2), prostate (84.6% 95% CI 83.6–85.6) and thyroid (84.2% CI 95% 82.0–86.6) cancers showed the highest 5-year relative survival, whereas the worst prognosis was observed in pancreatic (6% 95% CI 5.1–7.0) and oesophageal (9.4% 95% CI 7.9–11.1) cancers. Overall, survival is higher in women (58.0%) than in men (48.9%). The absolute difference in relative survival between 2000–2007 and 1995–1999 was positive for all cancers as a whole (+4.8% in men, +1.6% in women) and for most types of tumours. Survival increased significantly for chronic myeloid leukaemia, non-Hodgkin’s lymphoma and rectum cancer in both sexes, and for acute lymphoid leukaemia, prostate, liver and colon cancers in men and Hodgkin’s lymphoma and breast cancer in women. Survival patterns by age were similar in Europe and Spain. A decline in survival by age was observed in all tumours, being more pronounced for ovarian, corpus uteri, prostate and urinary bladder and less for head and neck and rectum cancers.
High variability and differences have been observed in survival among adults in Spain according to the type of cancer diagnosed, from above 84% to below 10%, reflecting high heterogeneity. The differences in prognosis by age, sex and period of diagnosis reveal opportunities for improving cancer care in Spain.
KeywordsCancer Survival Cancer registries Prognosis Population-based Spain
Compagnia Intesa San Paolo (Grant No. 2010.1354) and the Fondazione Cariplo (Grant No. 2010.1984).
REDECAN Working Group: Albacete (Antonio Mateos, Enrique Almar), Asturias (José Ramón Quirós, Marcial V. Argüelles, Virginia Menéndez), Canarias (Dolores Rojas, Araceli Alemán), Castellón (Ana Torrella, Consol Sabater, Paloma Botella), Ciudad Real (Matilde Chico, María Ripoll, Cristina Díaz), Infantil de la Comunitat Valenciana (Marisa Vicente, Nieves Fuster, Paloma Botella), Cuenca (José María Díaz, Rosario Jiménez, Ana Isabel Marcos Navarro), Euskadi-Basque Country (Nerea Larrañaga, Joseba Bidaurrazaga, Arantza Lopez-de-Munain), Girona (Rafael Marcos-Gragera, Àngel Izquierdo, Loreto Vilardell), Granada (María José Sánchez, Elena Molina-Portillo, Miguel Rodríguez-Barranco), La Rioja (Josefina Perucha), Mallorca (Paula Franch, Maria Ramos), Murcia (Carmen Navarro, María Dolores Chirlaque, Diego Salmerón), Navarra (Eva Ardanaz, Marcela Guevara, Rosana Burgui), Tarragona (Jaume Galceran, Alberto Ameijide, Marià Carulla, Jàmnica Bigorra), Registro Español de Tumores Infantiles (Rafael Peris Bonet, Elena Pardo).
Compliance with ethical standards
Conflict of interest
The authors declare that they have no conflict of interest.
This work does not contain clinical studies or patient data.
For this type of study formal consent is not required.
- 10.http://redecan.org/en/index.cfm. Accessed 2 Jun 2017.
- 11.http://www.EUROCARE.it. Accessed 2 Jun 2017.
- 13.Forman D, Bray F, Brewster DH, Gombe Mbalawa C, Kohler B, Piñeros M, et al. editors. Cancer incidence in five continents, vol. X. IARC scientific publication no. 164. Lyon: International Agency for Research on Cancer; 2014.Google Scholar
- 15.Fritz A, Percy C, Jack A, Shanmugaratnam K, Sobin L, Parkin M, et al. International classification of diseases for oncology. 3rd ed. Geneva: World Health Organization. 2000.Google Scholar
- 16.Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, et al., editors. WHO classification of tumours of haematopoietic and lymphoid tissues. Lyon: IARC; 2008.Google Scholar
- 17.IACR-ENCR. International rules for multiple primary cancers (ICD-O 3rd ed). Lyon: IACR; 2004. http://www.encr.eu/images/docs/recommendations/MPrules_july2004.pdf. Accessed 2 Jun 2017.
- 18.Spanish Data Protection Agency. https://www.agpd.es (2004). Accessed 2 Jun 2017.
- 19.European Network of Cancer Registries. Guidelines on confidentiality in population-based Cancer Registration in the European Union. Lyon: ENCR; 2002.Google Scholar
- 20.Ederer F, Heise H. Instructions to IBM 650 programmers in processing survival computations. Methodological note no. 10. End results evaluation section. National Cancer Institute: Bethseda; 1959.Google Scholar
- 23.Parkin DM, Hakulinen T. Cancer registration: principles and methods. Analysis of survival. IARC Sci Publ. 1991;95:159–76.Google Scholar
- 32.Romiti A, Falcone R, Roberto M, Marchetti P. Tackling pancreatic cancer with metronomic chemotherapy. Cancer Lett. 2017;394:88–95.Google Scholar
- 34.Gatta G, Botta L, Sánchez MJ, Anderson LA, Pierannunzio D, Licitra L, the EUROCARE Working Group. Prognoses and improvement for head and neck cancers diagnosed in Europe in early: the EUROCARE-5 population-based study. Eur J Cancer. 2015;51:2130–43.Google Scholar
- 37.Holleczek B, Rossi S, Domenic A, Innos K, Minicozzi P, Francisci S, EUROCARE-5 Working Group, et al. On-going improvement and persistent differences in the survival for patients with colon and rectum cancer across Europe 1999–2007—results from the EUROCARE-5 study. Eur J Cancer. 2015;51:2158–68.CrossRefPubMedGoogle Scholar
- 44.De Angelis R, Minicozzi P, Sant M, Dal Maso L, Brewster DH, Osca-Gelis G, EUROCARE-5 Working Group, et al. Survival variations by country and age for lymphoid and myeloid malignancies in Europe 2000–2007: results of EUROCARE-5 population-based study. Eur J Cancer. 2015;51:2254–68.CrossRefPubMedGoogle Scholar
- 46.Ellison LF. Differences in cancer survival in Canada by sex. Health Rep. 2016;27(4):19–27.Google Scholar