Role of taxanes in advanced prostate cancer
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Advanced prostate cancer is an androgen-dependent disease for which the initial treatment is an androgen deprivation maneuver. However, some primary resistances to hormonal treatment occur with increasing incidence throughout the evolution of the disease. The taxanes, docetaxel and cabazitaxel, exert their action at multiple levels at the tumor cell: besides inhibiting the mitosis and inducing the cell death, they induce the nuclear accumulation of FOXO1, a potent nuclear factor that acts against the activation of androgen receptor inhibiting the transcription of AR-V7 variant associated with the development of resistances to abiraterone and enzalutamide. Docetaxel, as first-line therapy, and cabazitaxel, as second-line therapy, have demonstrated to increase the survival in castration-resistant prostate cancer. The results from last studies either on high-risk localized disease or on androgen-sensitive tumors demonstrate the increasing role of taxanes at earlier states of prostate cancer.
KeywordsProstate cancer Docetaxel Cabazitaxel Androgen deprivation therapy AR splice variant
Medical writing assistance was provided by PIVOTAL S.L, funded by Sanofi. The authors are fully responsible for all content and editorial decisions for this manuscript. The authors indicate that they do not have any conflict of interests to declare.
Compliance with ethical standards
This article is a review of published studies, thus achievement of the patient Informed consent was not necessary.
Research involving human participants and/or animals
This article does not contain any studies with human participants or animals performed by any of the authors.
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