Clinical and Translational Oncology

, Volume 17, Issue 10, pp 788–794 | Cite as

Clinicopathological significance of orphan nuclear receptor Nurr1 expression in gastric cancer

  • J. Guo
  • G. Zu
  • T. Zhou
  • J. Xing
  • Z. WangEmail author
Research Article



Gastric cancer is the fourth most common cancer and the second leading cause of cancer-related deaths worldwide. Gastric cancer is characterized by high levels of invasion and metastasis. Increasing attention is being focused on discovering molecular markers for the diagnosis of gastric cancer and for predicting its prognosis. The objective of the present study was to evaluate Nurr1 expression in gastric cancer and to assess its correlation with clinicopathological parameters and prognosis in gastric cancer patients.


Tissue samples were obtained from 120 gastric cancer patients. We investigated Nurr1 expression in human normal and gastric cancer tissues using real-time reverse transcription polymerase chain reaction (qRT-PCR), western blotting, and immunohistochemistry. We determined the association between Nurr1 and recurrence, prognosis and patient clinicopathological parameters. Univariate and multivariate survival analyses with a Cox’s proportional hazards regression model were used to identify independent factors related to recurrence and prognosis.


The immunohistochemical, qRT-PCR and western blot analyses revealed that Nurr1 expression was increased in gastric cancer tissues compared with normal gastric tissue (P < 0.05). Nurr1 expression was significantly correlated with the tumor size, depth of tumor invasion, lymph node metastasis, recurrence, and distant metastasis of gastric cancer (P < 0.05). Moreover, Nurr1-high patients also exhibited poorer overall survival (OS) and disease-free survival compared with Nurr1-low patients (P < 0.01). The univariate and multivariate survival analyses suggested that Nurr1 expression (P = 0.011), histology (P = 0.018), depth of tumor invasion (P = 0.037), and presence of lymph node metastasis (P = 0.031) were independent prognostic factors for recurrence. In addition, Nurr1 expression (P = 0.007), depth of tumor invasion (P = 0.014), lymph node metastasis (P = 0.044), distant metastasis (P = 0.023), and recurrence (P = 0.011) were independent prognostic factors of OS in gastric cancer patients.


The Nurr1 protein may be useful as a marker of recurrence, metastasis, and poor prognosis following curative resection in patients with gastric cancer.


Gastric cancer Immunohistochemistry Prognosis Metastasis Nurr1 


Conflict of interest

There are no conflict of interests to disclose.


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Copyright information

© Federación de Sociedades Españolas de Oncología (FESEO) 2015

Authors and Affiliations

  1. 1.Department of Surgical OperationDalian Medical UniversityDalianPeople’s Republic of China
  2. 2.Department of General SurgeryThe Second Affiliated Hospital of Dalian Medical UniversityDalianPeople’s Republic of China
  3. 3.Department of NeurologyThe First Affiliated Hospital of Dalian Medical UniversityDalianPeople’s Republic of China
  4. 4.Department of General SurgeryThe Maternity and Child Care Institute of Dalian Xigang DistrictDalianPeople’s Republic of China
  5. 5.Department of General SurgeryThe First Affiliated Hospital of Dalian Medical UniversityDalianPeople’s Republic of China

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