Clinical and Translational Oncology

, Volume 17, Issue 2, pp 103–112 | Cite as

Biomarker testing in advanced non-small-cell lung cancer: a National Consensus of the Spanish Society of Pathology and the Spanish Society of Medical Oncology

  • E. FelipEmail author
  • Á. Concha
  • J. de Castro
  • J. Gómez-Román
  • P. Garrido
  • J. Ramírez
  • D. Isla
  • J. Sanz
  • L. Paz-Ares
  • F. López-Ríos
Educational series – Red Series New Trends in Clinical Oncology


In 2011, the Spanish Society of Medical Oncology and the Spanish Society of Pathology started a joint project to establish recommendations on biomarker testing in patients with advanced non-small-cell lung cancer based on the current evidence. Most of these recommendations are still valid, but new evidence requires some aspects to be updated. Specifically, the recommendation about which biomarkers to test in which patients is being amended, and the best way to manage tumour samples and minimum requirements for biomarker test material are defined. Suitable techniques for testing for epidermal growth factor receptor mutations and anaplastic lymphoma kinase rearrangement are also reviewed, and a consensus is reached on which situations warrant re-biopsy.


ALK Biomarkers EGFR Lung cancer 



The authors are grateful for the editorial assistance of Ana Martín of HealthCo (Madrid, Spain) in the production of this manuscript. F. López-Ríos thanks B. Angulo and E. Conde for their contribution to lung carcinoma targeted therapies. SEOM and SEAP are grateful for financial support for this project in the form of unrestricted grants from AstraZeneca, Boehringer Ingelheim, Lilly, Novartis, Pfizer and Roche.

Conflict of interest

The authors declare that, when writing and revising the text, they did not know the names of the pharmaceutical companies that provided financial support for this project, so this support has not influenced the content of this article.


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Copyright information

© Federación de Sociedades Españolas de Oncología (FESEO) 2014

Authors and Affiliations

  • E. Felip
    • 1
    Email author
  • Á. Concha
    • 2
  • J. de Castro
    • 3
  • J. Gómez-Román
    • 4
  • P. Garrido
    • 5
  • J. Ramírez
    • 6
  • D. Isla
    • 7
  • J. Sanz
    • 8
  • L. Paz-Ares
    • 9
  • F. López-Ríos
    • 10
  1. 1.Department of Medical Oncology, Oncology ServiceHospital Universitari Vall d’HebronBarcelonaSpain
  2. 2.Department of PathologyComplejo Hospitalario Universitario A CoruñaA CoruñaSpain
  3. 3.Department of Medical OncologyHospital Universitario La PazMadridSpain
  4. 4.Department of Pathology, Hospital Universitario Marqués de ValdecillaUniversidad de Cantabria, IDIVALSantanderSpain
  5. 5.Department of Medical OncologyHospital Universitario Ramón y CajalMadridSpain
  6. 6.Department of Pathology, Hospital Clinic, IDIBAPS, CIBERESUniversidad de BarcelonaBarcelonaSpain
  7. 7.Department of Medical OncologyHospital Clínico Lozano BlesaZaragozaSpain
  8. 8.Department of Pathology, Facultad de MedicinaUniversidad Complutense de Madrid, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC)MadridSpain
  9. 9.Department of Medical OncologyInstituto de Biomedicina de Sevilla, IBIS (Hospital Universitario Virgen del Rocío, Universidad de Sevilla, CSIC)SevilleSpain
  10. 10.Laboratorio de Dianas Terapéuticas, Department of PathologyHospital Universitario SanchinarroMadridSpain

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